Effect of the hypophyseal preparation adiposin on the lipolytic activity of adipose tissue and on the serum concentration of free higher fatty acids

Summary

Subject to study was the effect produced by adiposin, a hypophyseal preparation obtained by S. M. Leites and A. A. Molchanova, on the lipolytic activity of adipose tissue and the NEFA content in the rat serum. In experiments in vitro and in vivo a demonstration was made of the activating effect produced by low doses of adiposin (0.01 mg in vitro and 1.5 mg—in vivo) on NEFA exit from the adipose tissue with a parallel considerable rise in their content in the serum. Adiposin also retards glucose inhibition of lipolysis in the adipose tissue. It is supposed that adipokinetic affect of adiposin is due not only to activation of lipolysis by it in the adipose tissue, but also to the triglyceride synthesis in the latter.