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Experimental data on the action of a number of organophosphorous compounds on the motor function of the rabbit's intestine

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Investigations have been made on the effects on the muscles of the rabbit's intestine of compounds which reduce the activity of cholinesterase: a) in vitro and in vivo (pyrophos, isosystox, methylacetophos); b) slowly in vitro but more actively in vivo (octamethyl, chlorophos, M-81, M-81 Su 3) and c) neither in vitro nor in vivo (K-20-35).

From the results of the experiments it was determined that the substances in the first group began to cause an increase of the intestinal contractions in periods ranging from several seconds to 3–8 min; the compounds of the 2rd group in periods from 15–40 min and the preparations of the 3rd group had no effect on the intestinal motor functions.

It was noted that the esters of thiophosphoric acid (isosystox, acetophos, methylacetophos) exerted a stronger action on the transverse muscles and pyrophos, octamethyl, chlorophos, M-81 and M-81 Su 3 had a stronger action on the longitudinal muscles. According to their capacity for increasing peristalsis, the best preparations were M-81, M-81 Su 3, pyrophos, and octamethyl.

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Authors and Affiliations

  1. Surgical Department of the Highway Hospital No. 2 of the Southwestern Railway, Kiev Institute of Industrial Hygiene and Occupational Diseases, Kiev, USSR

    A. P. Gel'fer

  2. Toxicological Laboratory, Kiev Institute of Industrial Hygiene and Occupational Diseases, Kiev, USSR

    A. P. Gel'fer

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  1. A. P. Gel'fer
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Gel'fer, A.P. Experimental data on the action of a number of organophosphorous compounds on the motor function of the rabbit's intestine. Bull Exp Biol Med 59, 535–538 (1965). https://doi.org/10.1007/BF00783078

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  • DOI: https://doi.org/10.1007/BF00783078

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