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The use of certain hormones of the hypophysis and adrenals in the prevention and treatment of shock due to prolonged compression of soft tissues

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Experiments were performed on 165 rats. The therapeutic efficacy of ACTH, hydrocortisone acetate and noradrenalin was tested in prolonged crush-syndrome. Special clamps were applied to the thigh for a period of 8 hours.

Prophylactic and therapeutic administration of ACTH improved the condition of the animals; as a result of this, survival rate and the life span were considerably increased. Cortisone also improved the state of the animals and lengthened their lives. Analogous results were obtained in noradrenalin administration. DOCA aggravated the animals' condition by increasing edema of the injured tissues and hemorrhages. In large doses DOCA exerted a negative effect on the survival and the life span of experimental animals.

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Authors and Affiliations

  1. Department of Pathological Physiology, the Order of Lenin S. M. Kirov Military Medical Academy, USSR

    V. K. Kulagin

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  1. V. K. Kulagin
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Kulagin, V.K. The use of certain hormones of the hypophysis and adrenals in the prevention and treatment of shock due to prolonged compression of soft tissues. Bull Exp Biol Med 49, 562–565 (1960). https://doi.org/10.1007/BF00782105

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  • DOI: https://doi.org/10.1007/BF00782105

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