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Transplantation of bone marrow in rats with sarcoma M-1 after the use of toxic doses of thioTEPA

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

A study was made of the effect of the bone marrow transplantation in rats of the Wistar line with sarcoma M-1 treated with toxic ThioTEPA doses.

The bone marrow transplantation contributed to the survival of rats after a single dose of thioTEPA—12.5 mg/kg — or following its repeated administration in a total course dose of 27.3 mg/kg body weight. Tumor regression was noted after a repeated administration of the preparation, whereas single doses caused but temporary inhibition of the tumor growth.

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Authors and Affiliations

  1. Laboratory of Experimental Tumor Therapy, P. A. Gertsen State Oncological Institute, Moscow

    G. M. Sukhin

Authors
  1. G. M. Sukhin
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Sukhin, G.M. Transplantation of bone marrow in rats with sarcoma M-1 after the use of toxic doses of thioTEPA. Bull Exp Biol Med 59, 81–84 (1965). https://doi.org/10.1007/BF00782073

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  • DOI: https://doi.org/10.1007/BF00782073

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