Immunophysiological changes in homotransplantation of dog extremities

Summary

Hornotransplantation of the left posterior extremity was carried out in 8 adult dogs. In the presence of the blood incompatibility the recipient died on the 5th–10th day after the operation. In the rest of the cases the transplant became detached on the 6th–14th day. The excitability of the muscles of the transplanted extremity may be restored after the degeneration of the neuromuscular synapses. The capacity of the homotransplanted extremity for direct muscular excitability is an important compensatory reaction of the transplanted organ. Primary “take” of the extremity was accompanied by the accumulation of complete and incomplete hemagglutinins in the recipient's serum from the 3rd day after the transplantation (1:2–1:32 titers). A rise in the antibody titer was observed by the 6th–9th post-transplantation day which coincided in time with the onset of the homotransplant necrosis.