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On the effect of prolonged nociceptive (pain) stimuli on the heating of experimental cutaneous wounds

  • Oncology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

A study was made of the effect produced by prolonged nociceptive (pain) stimulation on healing of cutaneous wounds in rats. In the first experimental series, carried out during the summer and winter months, prolonged stimulation of both sciatic nerves was applied (40 rats), whereas in the second series, the sciatic nerve was stimulated only on one side (40 rats). Half of the animals in both series served as the control. As demonstrated, wound healing was biphasic: during the first 6–8 days, prolonged nociceptive stimulation stimulated wound healing, whereas at a later period, it inhibited it. Wound healing occurred 5 to 7 days earlier in control rats than in the experimental animals. Asymmetry in healing of the skin wounds was observed: the wounds healed 48 h later on the side of the stimulation.

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Authors and Affiliations

  1. Department of Normal Physiology of the Blagoveschensk Medical Institute, Blagoveschensk, USSR

    V. V. Kravtsov

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  1. V. V. Kravtsov
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Kravtsov, V.V. On the effect of prolonged nociceptive (pain) stimuli on the heating of experimental cutaneous wounds. Bull Exp Biol Med 57, 361–363 (1964). https://doi.org/10.1007/BF00781929

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  • DOI: https://doi.org/10.1007/BF00781929

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