Summary
The high diversity of collagen expression and its qualitative and quantitative aspects are demonstrated in pleomorphic adenoma using electron microscopy and specific histochemical methods. Great variability was observed in the amount, distribution and characteristics of the collagen found in the various types of tissue normally present in this tumour. Both deficient polymerization and hyperpolymerization of collagen and the occurence of desmoplasia were observed. Evidence is presented to suggest a role for localized collagenolysis in the invasiveness of this neoplasia.
Similar content being viewed by others
References
Azzopardi JG, Smith OD (1959) Salivary gland tumors and their mucins. J Pathol Bacteriol 77:131–140
Azzopardi JG, Zayid I (1972) Elastic tissue in tumors of salivary glands. J Pathol 107:149–156
Barsky SH, Grotendorst GR, Liotta LA (1982) Increased content of type V collagen in desmoplasia of human breast carcinoma. Am J Pathol 108:276–283
Brownstein M, Shapiro L (1977) Desmoplastic trichoepithelioma. Cancer 40:2979–2986
Campbell WG Jr, Priest RE, Weathers DR (1985) Characterization of two types of crystalloids in pleomorphic adenomas of minor salivary glands. A light-microscopic, electron microscopic, and histochemical study. Am J Pathol 118:194–202
Caselitz J, Seifert G, Jaup T (1982) Tumor antigens in neoplasms of the human parotid gland. J Oral Pathol 11:374–386
Caselitz J, Osborn M, Hamper K, Wustrow J, Rauchfub A, Weber K (1986) Pleomorphic adenomas, adenoid cystic carcinomas and adenolymphomas of salivary glands analysed by a monoclonal antibody against myoepithelial basal cells. An immunohistochemical study. Virchows Arch [A] 409:805–816
Caselitz J, Schmitt P, Seifert G, Wustrow J, Schuppan D (1988) Basal membrane associated substances in human salivary glands and salivary gland tumors. Pathol Res Pract 183:386–394
Dardick I, Peter van Nostrand AW, Jeans MTD, Rippstein P, Edwards V (1983) Pleomorphic adenoma I. Ultrastructural organization of “epithelial” regions. Hum Pathol 14:780–797
Dardick I, Peter van Nostrand AW, Jeans MTD, Rippstein P, Edwards V (1983a) Pleomorphic adenoma II. Ultrastructural organization of “stromal” regions. Hum Pathol 14:798–809
David R, Buchner A (1980) Elastosis in benign and malignant salivary gland tumors. A histochemical and ultrastructural study. Cancer 45:2301–2310
David R, Buchner A (1982) Tannic acid-glutaraldehyde fixative and pleomorphic adenomas of the salivary gland: an ultrastructural study. J Oral Pathol 11:26–38
Erlandson RA, Cardon-Cardo C, Higgins PJ (1984) Histogenesis of benign pleomorphic adenoma (mixed tumor) of the major salivary glands. An ultrastructural and immunohistochemical study. Am J Surg Pathol 8:803–820
Foot FW, Frazell EI (1953) Tumors of the major salivary glands. Cancer 6:1065–1133
Iozzo RV (1984) Proteoglycans and neoplastic-mesenchymal cell interactions. Hum Pathol 15:2–10
Jiwa M, Van der Hoof A (1985) The possible role of stromal influences in tumor cell heterogeneity. Histology and fibronectin pattern of the Yoshida sarcoma of the rat. Anticancer Res 5:273–276
Junqueira LCU, Cossermelli W, Brentani R (1978) Differential staining of collagens type I, II and III by Sirius Red and polarization microscopy. Arch Hist Jpn 41:267–274
Junqueira LCU, Bignolas G, Brentani RR (1979) Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem J 11:447–455
Junqueira LCU, Zugaib M, Monates GS, Toledo OMS, Krisztan RM, Shigihara (1980) Morphologic and histochemical evidence for the occurrence of collagenolysis and for the role of neutrophilic polymorphonuclear leukocytes during cervical dilatation. Am J Obstet Gynecol 138:273–281
Junqueira LCU, Montes GS, Kaupert D, Shigihara KM, Bolonhani TM, Krisztan RM (1981) Morphological and histochemical studies on the collagen in neurinomas, neurofibromas and fibromas. J Neuropathol Exp Neurol 40:123–133
Junqueira LCU, Roscoe JT (1985) Reduced collagen content and fibre bundle disorganization in skin biopsies of patients with Erler-Danlos syndrome. Histochem J 17:1197–1202
Junqueira LCU, Figueiredo MTA, Torloni H, Montes GS (1986) Differential histologic diagnosis of osteoid. A study of human osteosarcoma collagen by the histochemical Picrosirius- polarization method. J Pathol 148:189–196
Kahn HJ, Baumal R, Marks A, Dardick I, Peter van Nostrand AW (1985) Myoepithelial cells in salivary gland tumors. An immunohistochemical study. Arch Pathol Lab Med 109:190–195
Krepler R, Denk H, Artlieb U, Moll R (1982) Immunocytochemistry of intermediate filament proteins present in pleomorphic adenomas of the human parotid gland: Characterization of different cell types in the same tumor. Differentiation 21:191–199
Lam RMY (1985) An electron microscopic histochemical study of the histogenesis of major salivary gland pleomorphic adenoma. Ultrastruct Pathol 8:207–223
Line SRP, Torloni H, Montes GS, Junqueira LCU (1988) A note on the histochemical and morphological characterization of the asbestoid degeneration of cartilage. Histochemistry 88:411–413
Liotta LA, Rao CN, Barski SH (1983) Tumor invasion and extracellular matrix. Lab Invest 49:636–649
Lovell D, Briggs JC, Schorah CJ (1966) Chemical analysis of acid mucopolysaccharides of mixed salivary tumors. Br J Cancer 20:463–468
Martinez-Hernandez A, Amenta PS (1983) The basement membrane in pathology. Lab Invest 48:656–677
McCurley TL, Gay RE, Gay S, Glick AD, Haralson MA, Collins RD (1986) The extracellular matrix in “sclerosing” follicular center cell lymphomas: An immunohistochemical and ultrastructural study. Hum Pathol 17:930–938
Montes GS, Bezerra MSF, Junqueira LCU (1984) Collagen distribution in tissues. In: Ruggeri A, Motta PM (eds) Ultrastructure of the connective tissue matrix. Martinus Nijhof Publishers, Boston, Printed in The Netherlands
Nakazato Y, Ishizeki J, Takahashi K, Yamaguchi H, Kamei T, Mori T (1982) Localization of S-100 protein and glial fibrillary acidic protein-related antigen in pleomorphic adenoma of the salivary glands. Lab Invest 46:621–626
Nemeth Csoka M, Kovacsay A (1979) The effect of glycosaminoglycans on the vitro fibril formation of type I and III collagen. Exp Pathol 17:82–87
Palmer RM, Lucas RB, Knight J, Gusterson B (1985) Immunocytochemical identification of cell types in pleomorphic adenoma, with particular reference to myoepithelial cells. J Pathol 146:213–220
Quintarelli G, Robinson L (1967) The glycosaminoglycans of salivary gland tumors. A histochemical characterization and a critical evaluation. Am J Pathol 51:19–37
Rovasio RA, Fonseca MM, Gendelman H, Morris B (1980) Histochemistry of glycoconjugates of pleomorphic adenomas of minor salivary glands, with special reference to glycocalyx of tubular areas. Oral Surg, Oral Med, Oral Pathol 50:58–61
Seifert G, Langrock I, Donath K (1976) A Pathological classification of pleomorphic adenoma of the salivary glands. HNO 24:415–426
Takeuchi J, Sobue M, Yoshida M, Esaki T, Katoh Y (1975) Pleomorphic adenoma of the salivary gland. With special reference to histochemical and electron microscopic studies and biochemical analysis of glycosaminoglycans in vivo and in vitro. Cancer 36:771–1784
Thackray AC, Lucas RB (1974) Tumors of the major salivary glands. Atlas of Tumor Pathology, section 2, fascicle 10, Washington, Armed Forces Institute of Pathology, pp 16–39
Tryggvanson K, Hoyhtya M, Salo T (1987) Proteolytic degradation of extracellular matrix in tumor invasion. Biochim Biophys Acta 90:191–217
Valensi QJ (1979) Desmoplastic malignant melanoma. A light and electron microscopic study of two cases. Cancer 43:1148–1155
Welsh RA, Meyer AT (1968) Mixed tumors of human salivary gland Histogenesis. Arch Pathol 85:433–447
Yates PO, Paget GE (1952) A mixed tumour of salivary gland showing bone formation, with a histochemical study of the tumor mucoids. J Pathol Bacteriol 64:881–888
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Line, S.R.P., Torloni, H. & Junqueira, L.C.U. Diversity of collagen expression in the pleomorphic adenoma of the parotid gland. Vichows Archiv A Pathol Anat 414, 477–483 (1989). https://doi.org/10.1007/BF00781704
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00781704