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Remodeling the Architecture of Collagen-Containing Connective Tissue Fibers of Metastatic Prostate Cancer

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An Erratum to this article was published on 04 December 2023

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Abstract

The morphological study was aimed at determining the role of fibrillar organization of the collagen-containing connective tissue of prostate cancer at the stage of neoplastic proliferation, including metastatic spreading into bone tissue. The histological material of 55 patients with prostate cancer, Gleason six to nine malignancy score, without neoplastic proliferation and with metastases into bones, was used. The architectural specificities of collagen-containing connective tissue of neoplasms were determined using Van Gieson’s method. It was found that the remodeling of collagen-containing connective tissue around the epithelial tumor structures with aggressive prostate cancer (Gleason score of eight to nine) resulted in the increase in the percentage of extended and flattened fibrils as compared to curved fibrils; the adjacent and surrounding stroma was notable for the enlarged total area of collagen-containing fibrils, manifestations of desmoplasia, compactization of the location, widening, flattening, and extending. The data obtained demonstrate that the remodeling of collagen-containing connective tissue components of prostate cancer conditions unrestricted migration and invasion of tumor cells, including those expressing the proteins involved in bone tissue remodeling.

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Authors and Affiliations

  1. R.E. Kavetsky Institute of Experimental Pathology, Oncology, and Radiobiology, National Academy of Sciences of Ukraine, 03022, Kyiv, Ukraine

    L. A. Naleskina, N. Yu. Lukianova, T. V. Zadvornyi, L. M. Kunska, O. M. Mushii & V. F. Chekhun

Authors
  1. L. A. Naleskina
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  2. N. Yu. Lukianova
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  3. T. V. Zadvornyi
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  4. L. M. Kunska
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  5. O. M. Mushii
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  6. V. F. Chekhun
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Correspondence to L. A. Naleskina, N. Yu. Lukianova, T. V. Zadvornyi, L. M. Kunska, O. M. Mushii or V. F. Chekhun.

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Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

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Translated by V. Mittova

The original online version of this article was revised: Modifications have been made to the Affiliations.

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Naleskina, L.A., Lukianova, N.Y., Zadvornyi, T.V. et al. Remodeling the Architecture of Collagen-Containing Connective Tissue Fibers of Metastatic Prostate Cancer. Cytol. Genet. 57, 406–412 (2023). https://doi.org/10.3103/S0095452723050031

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