Changes in the blood pressure and their mechanism of development after injection of hypertonic solutions into the blood stream

Summary

Following quick intravenous injection of hypertonic glucose and sodium chloride solution, the arterial blood pressure in dogs increases in 2 waves with a depressor wave in-between. It then drops and subsequently rises to its initial level.

The author conducted experiments with catheterization of the cardiac cavities and of the great vascular trunks, with prefusion of the isolated pulmonary lobe and extremity. It was demonstrated that the changes of the blood pressure described above are determined by a successive stimulation with hypertonic solution of reflexogenic zones of the pulmonary circulation, the great arterial trunks, the peripheral vascular network (with a possible paticipation of the peripheral mechanisms). In strong stimulation powerful depressor reflexes from the receptors of the pulmonary circulation are prevalent with constriction of the pulmonary vessels. This brings about a sharp temporary rise of the blood pressure in the pulmonary artery and a fall of the general arterial pressure. The main afferent and efferent mechanisms and scheme of the reaction are described.