Summary
Experiments were performed on rat's fetuses from the 17th to the 20th day of their development. The author studied the normal histogenesis and reactive changes occurring in the epidermis by injection of an extract of naphthalan oil into it.
Morphological observations were compared with the study of the intensity of S35 incorporation during the course of normal histogenesis and development of the reactive process in the epithelium.
The comparison of morphological and autoradiographical data demonstrated a conformity between the initial stage of the keratinization of the stratum and a selective increase of the intensity of S35 incorporation in the keratinizing cells and those which are preparatory to keratinization. An analogous regularity has been revealed, experimentally, in artificial stimulation of processes of keratinization in the epidermis. The increase of S35 incorporation intensity in the traumatized epithelium does not exceed the level of its accumulation by the normal epidermis of the more mature embryos. A suggestion is made that normal histogenesis and reactive changes of the embryonic epithelum are based on general regularities.
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Zavarzin, A.A. The action of an extract of naphthalan oil on the epidermis of the embryo and its effect on the take-up of radiosulfur (S35-methionine). Bull Exp Biol Med 47, 627–632 (1959). https://doi.org/10.1007/BF00779692
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DOI: https://doi.org/10.1007/BF00779692