Summary
The authors investigated the effect of tetraethylammonium, Pentamine, and hexamethonium on reflexes from the urinary bladder to the colon, ileum, and jejunum, and on the reflex contractions of the urinary bladder following stimulation of the central end of the sectioned hypgastric nerve, after preliminary section (3–30 days previously) of all the preganglionic fibers of the inferior mesenteric ganglion. This was done to ascertain the mechanism of action of the ganglioplegics on peripheral viscero-visceral reflexes. It was found that these substances continued to depress the reflexes mentioned after degeneration of the preganlionic axons of the inferior mesenteric ganglia.
Thus the data obtained demonstrate that the ganglionic blocking agents depress local reflexes, thus inhibiting the transmission of excitation in autonomic ganglia from afferent to efferent neurons.
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V. V. Zakusov and O. V. Ul'yanova, Farmakol. i toksikol.21, 2, 3–8 (1958).
I. P. Razenkov, Zhurn. eksperim. biol. i med.3, 66 (1926).
N. M. Sokovnin, Izvestiya i uchenye zapiski kazanskogo universiteta44, 5, 1243 (1877).
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Translated from Byulleten' eksperimental'noi biologii i meditsiny Vol. 49, No. 1, pp. 75–78, January, 1960
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Zakusov, V.V., Ul'yanova, O.V. On the mechanism of action of ganglioplegics on peripheral viscero-visceral reflexes. Bull Exp Biol Med 49, 61–63 (1960). https://doi.org/10.1007/BF00779578
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DOI: https://doi.org/10.1007/BF00779578