Summary
The author conducted an autoradiographic investigation of the thyroid gland at various intervals after the administration of radioiodine to rats. The method of liquid emulsion coating was used. Paraffin sections prepared at intervals of 30 minutes to 1 hour produce an autoradiographic ring reaction which, in the main, corresponds to the peripheral zone of the intrafollicular colloid. By using frozen sections devoid of the colloid the author established the presence of small quantities of protein-bound iodine in the thyroid epithelium. Radiochromatographic investigation of thyroid tissue hydrolyzates at different intervals after radioiodine administration points to the fact that, during the interval of 1–24 hours, when the bulk of the protein-bound iodine is in the colloid, the amount of radioiodothyronines increased at the expense of radioiodotyrosine. A conclusion is drawn that the formation of iodine-containing organic compounds in the thyroid gland begins in the epithelial cells and continues in the follicular lumen.
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Levenson, V.I. The site of the synthesis of protein-bound iodine in the thyroid gland. Bull Exp Biol Med 49, 51–53 (1960). https://doi.org/10.1007/BF00779575
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DOI: https://doi.org/10.1007/BF00779575