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The barrier function of the lymph nodes in infection

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

Fixation ofB. coli commune by the popliteal lymph nodes was studied as follows: Lymph nodes were perfused by a suspension ofB. coli commune, and studies were made of lymph taken at operation by means of fistulae in the thoracic duct and lymphatic vessels of a dog's hind limb. The ability of the lymph node to fixate bacteria is increased by immunization, particularly when the immunizing culture is injected into the area corresponding to the given node. The barrier function of the nodes increases, particularly when inflammation is provoked in them either by infectious or noninfectious agents. The nonspecific phenomena, which include intensification of the mechanical filtration and increase of phagocytic activity of the cells of the node play a significant part in the increase of lymph node barrier function in immunization.

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Authors and Affiliations

  1. Department of Pathological Physiology, M. I. Pirogov Moscow State Medical Institute, Moscow, USSK

    N. V. Medunitsyn

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  1. N. V. Medunitsyn
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Medunitsyn, N.V. The barrier function of the lymph nodes in infection. Bull Exp Biol Med 49, 40–43 (1960). https://doi.org/10.1007/BF00779572

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  • DOI: https://doi.org/10.1007/BF00779572

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