Skip to main content
SpringerLink
Log in

The action mechanism of reserpine compared with that of certain other tranquilizing substances

  • Pharmacology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Summary

A study of the effect of reserpine in comparison with the action of Aminazine, Diphacyl, Antiffeine, strophanthidin and Sygethin has demonstrated differences in the mechanism of their action.

After blocking monoaminoxidase with phenylisopropyl hydrazine or iproniazide, the sedative, hypotensive and hypothermic effects of reserpine are inverted, whereas the pharmacological action of Aminazine, Diphaycl. Antiffeine, strophanthidin and Sygethin does not change materially.

The mechanism of reserpine action consists of its ability to liberate adrenalin, noradrenalin and serotinin from different tissues; the action of other preparations studied in this work (according to literature data) is caused by other mechanisms.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature Cited

  1. Anichkov, S. V., in: New Medicinal Substances in Experiments and in Clinics [in Russian] (Leningrad, 1958) p. 5.

  2. Asratyan, S. N., in: Selective Effects of Medicinal Substances on the Central Nervous System [in Russian] (Leningrad, 1958) p. 51.

  3. Borodkin, Yu. S., in: 1957 Annual of the Institute of Experimental Medicine [in Russian] (Leningrad, 1958) p. 163.

  4. Denisenko, P. P., in: Expanded Abstracts of the Proceedings at the Symposia of the 9th Congress of the All-Union Society of Physiologists, Biochemists and Pharmacologists [in Russian] (Moscow-Minsk, 1959) Vol. 3, p. 209.

  5. Liberman, S. S., Zhurn. Nevropatol. i Psikhiat.59, 4, 396 (1959).

    Google Scholar 

  6. Besendorf, H., and Pletscher, A., Hel. physiol. pharmacol. Acta14, 383 (1956).

    Google Scholar 

  7. Brodie, B. B., Pletscher, A., and Shore, P. A., J. Pharmacol. and Exp. Ther.116, 84 (1956).

    Google Scholar 

  8. Chessin, M., Kramer, E. R., and Scott, C. C., J. Pharmacol. and Exp. Ther.119, 453 (1957).

    Google Scholar 

  9. Davison, A. N., Lessin, A. W. and Parkes, M. W., Experientia13, 329 (1957).

    Google Scholar 

  10. Holtz, P., Balzer, H., Westermann, E. et al., Arch. exp. Path. Pharmakol.231, 333 (1957).

    Google Scholar 

  11. Holzbauer, M. and Vogt, M., Neurochem.1, 8 (1956).

    Google Scholar 

  12. Horita, A., J. Pharmacol. exp. Ther.122, 176 (1958).

    Google Scholar 

  13. Paasonen, M. K. and Vogt, M. J., Physiol.131, 617 (1956).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Pharmacology of the AMN SSSR Institute of Experimental Medicine, Leningrad

    Wu Hsi-jui

Authors
  1. Wu Hsi-jui
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hsi-jui, W. The action mechanism of reserpine compared with that of certain other tranquilizing substances. Bull Exp Biol Med 51, 461–465 (1961). https://doi.org/10.1007/BF00779534

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00779534

Keywords

Search

Navigation