Abstract
The in vitro synthesis of RNA in the human placental tissue, incubated in organ culture, was investigated. We followed the synthesis of the poly A(-) and poly A(+) RNA fractions, and investigated the distribution of the newly synthesized RNA among the subcellular fractions isolated from first and third trimester placentas.
The poly A(-) RNA was the major fraction of the RNA synthesized in vitro. The incorporation of [3H]uridine into the poly A(+) RNA fraction was very low.
As protein synthesis occurred during the entire incubation period, we suggest the presence of a pool of mRNA molecules in the form of mRNP particles.
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Lorberboum, H., Weinstein, D., Galski, H. et al. RNA synthesis in cultured human placenta. Mol Biol Rep 8, 103–110 (1982). https://doi.org/10.1007/BF00778512
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DOI: https://doi.org/10.1007/BF00778512