Abstract
In this paper, a hypothesis is described according to which mobile dispersed genetic elements are related to endogenous viral genomes and may be involved in oncogenic transformation by uptaking cellular genes important for cellular growth. It is also possible that, in certain cases, they can switch off the genes involved in the control of differentiation.
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GeorgievG.P., Y.V.Ilyin, A.P.Ryskov, N.A.Tchurikov, G.N.Yenikolopov, V.A.Gvozdev & E.V.Ananiev. Science 195: 394 (1977).
IlyinY.V., N.A.Tchurikov, E.V.Ananiev, A.P.Ryskov, G.N.Yenikolopov, S.A.Limborska, N.E.Maleeva, V.A.Gvozdev & G.P.Georgiev. Cold Spring Harbor Symp. Quant. Biol. 42: 959 (1978).
FinneganD.J., G.M.Rubin, M.W.Young & HognessD. Cold Spring Harbor Symp. Quant. Biol. 42: 1053 (1978).
TchurikovN.A., Y.V.Ilyin, E.V.Ananiev & G.P.Georgiev. Nucleic Acids Res. 5: 2169 (1978).
AnanievE.V., V.A.Gvozdev, Y.V.Ilyin, N.A.Tclturikov & G.P.Georgiev. Chromosoma 70: 1 (1978).
CameronJ.R., E.Y.Loh & R.W.Davis. Cell 16: 739 (1979).
Georgiev, G.P., Y.V. Ilyin, V.G. Chmeliauskaite, D.A. Kramerov, A.P. Ryskov, A.S. Krayev, K.G. Skrjabin & E.M. Lukanidin. Cold Spring Harbor Symp. Quant. Biol. 45 (1981) in press.
PotterS.S., W.J.BroreinJr., P.Dunsmuir & G.M.Rubin. Cell 17: 415 (1979).
StrobelE., P.Dunsmuir & G.M.Rubin. Cell 17: 429 (1979).
YoungM.W.. Proc. Natl. Acad. Sci. USA 76: 6274 (1979).
Ilyin, Y.V., V.G. Chmelisukaite, E.V. Ananiev & G.P. Georgiev. Chromosoma (1980) in press.
Ilyin, Y.V., V.G., Chmeliauskaite, E.V. Ananiev, V.V. Kulguskin, A.A. Bayev Jr., N.V. Lyubomirskaya & G.P. Georgiev. Nucleic Acids Res., submitted for publication (1980).
TchurikovN.A., E.S.Zelentsova & G.P.Georgiev. Nucleic Acids Res. 8: 1243 (1980).
BayevA.A., A.S.Krayev, N.V.Lyubomirskaya, K.G.Skrjabin, Y.V.Ilyin & G.P.Georgiev. Nucleic Acids Res. 8: 3263 (1980).
Zachariev, V.S., A.A. Bayev, V.V. Kulguskin, K.G. Skrjabin, Y.V. Ilyin & G.P. Georgiev. (unpublished results).
Rubin, G.M. Personal communication.
Ilyin, Y.V., V.G. Chmeliauskaite, V.V. Kulguskin & G.P. Georgiev. Nucleic Acid Res., submitted.
IlyinY.V., ChmeliauskaiteV.G. & G.P.Georgiev. Nucleic Acids Res. 8: 3439 (1980).
KramerovD.A., A.P.Ryskov & G.P.Georgiev. Biochim. Biophys. Acta 475: 461 (1977).
Tchurikov, N.A., Y.V. Ilyin, K.G. Skrjabin, E.V. Ananiev, A.A. Bayev, A.S. Krayev, E.S. Zelentsova & G.P. Georgiev. Cold Spring Harbor Symp. Quant. Biol. 45 (1981) in press.
Gvozdev, V.A., E.S. Beljaeva, Y.V. Ilyin, I.S. Amosova & L.Z. Kajdanov. Cold Spring Harbor Symp. Quant. Biol. 45 (1981) in press.
IsingG. & C.Ramel. In: The Genetics and Biology of Drosophila, (M.Ashburner & E.Novitski, eds) Academic Press, NY, pp. 947 (1976).
GehringW. & R.Paro. Cell 19: 897 (1980).
StanfieldS.W. & D.R.Helinski. Cell 9: 333 (1976).
StanfieldS.W. & J.A.Lengyel. Proc. Natl. Acad. Sci. USA 76: 6142 (1979).
RyskovA.P., V.G.Farashyan & G.P.Georgiev. Biochim. Biophys. Acta 262: 568 (1972).
JelinekW. & J.E.Darnell. Proc. Natl. Acad. Sci. USA 69: 2537 (1972).
RyskovA.P., D.A.Kramerov & G.P.Georgiev. Biochim. Biophys. Acta 447: 214 (1976).
GeorgievG.P., A.J.Varshavsky, A.P.Ryskov & R.B.Church. Cold Spring Harbor Symp. Quant. Biol. 38: 869 (1974).
KramerovD.A., A.G.Grigorian, A.P.Ryskov & G.P.Georgiev. Nucleic Acids Res. 6: 697 (1979).
KramerovD.A. & A.P.Ryskov. Mol. Biol. (USSR) 13: 601 (1979).
RozinovaE.N. in “Tumor growth as a problem of developmental biology” (M.S.Mitskievich, ed.) Nauka, Moscow, pp. 26–81 (1979).
CanaaniE. & S.A.Aaronson. Proc. Natl. Acad. Sci. USA 76: 1677 (1979).
GilboaE., S.W.Mitra, S.Goff & D.Baltimore. Cell 18: 93 (1979).
RothenbergE., D.J.Donoghue & D.Baltimore. Cell 13: 435 (1978).
MellonP. & P.H.Duesberg. Nature 270: 631 (1977).
Bishop, J.M., C.T. Deny, B.W.J. Mahy, N. Quintrell, E. Stavnerer & H.E. Varmus. In: Animal Virology JCN-UCLA Symp. on Molecular and Cellular Biology (D. Baltimore, ed.) pp. 1–20 (1976).
Cold Spring Harbor Symp. Quant. Biol. vol. 44 (1980).
SpectorD.H., H.E.Varmus & J.M.Bishop. Proc. Natl. Acad. Sci. USA 75: 4102 (1978).
StehelinD., H.E.Varmus & J.M.Bishop. Nature 260: 170 (1976).
LevinsonA.D., H.Oppermann, L.Levintow, H.Varmus & J.M.Bishop. Cell 15: 561 (1978).
CollettM.S. & R.L.Erikson. Proc. Natl. Acad. Sci. USA 75: 2021 (1978).
RohrschneiderL.R., R.N.Eisenman & C.R.Leitch. Proc. Natl. Acad. Sci. USA 76: 4479 (1979).
WangL.-H., C.C.Halpern, M.Nadel & H.Hanafusa. Proc. Natl. Acad. Sci. USA 75: 5812 (1978).
FrolovaE.I. & G.P.Georgiev. Nucleic Acids Res 7: 1419 (1979).
RappU.R. & G.J.Todaro. Proc. Natl. Acad. Sci. USA 77: 624 (1980).
GateffE., Biological Reviews 53 (part 1): 123 (1978).
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Georgiev, G.P., Ilyin, Y.V., Ryskov, A.P. et al. Mobile dispersed genetic elements and their possible relation to carcinogenesis. Mol Biol Rep 6, 249–254 (1980). https://doi.org/10.1007/BF00777533
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DOI: https://doi.org/10.1007/BF00777533