Abstract
We present here an attempt to build up a space-filling model of the nucleosome core particle based on the chemical crosslinking data of Mirzabekov and coworkers (23). It is shown that the models proposed earlier are inconsistent with the results of these authors. The main characteristics of our model are as follows: a) the DNA superhelix contains at least 90 base pairs (bp) per turn; b) the particle has a dyad axis of symmetry; c) the histone octamer may be regarded as consisting of two heterotypic tetramers. The possible shape and function of core histones are discussed in the light of the model.
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Khachatrian, H.T., Pospelov, V.A. Spatial organization of histones and DNA in the nucleosome core particle: A model. Mol Biol Rep 6, 219–223 (1980). https://doi.org/10.1007/BF00777528
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DOI: https://doi.org/10.1007/BF00777528