Conclusions
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1.
It was shown that the yield and quality of the potassium salt of penicillin in the case of vacuum evaporation of a concentrate depend on the degree of evaporation of the mixture.
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2.
Better yields (85–90%) and quality of the potassium salt of penicillin are achieved when vacuum evaporation of the mixture is conducted to the original volume of the penicillin concentrate.
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3.
The course of the vacuum, evaporation process should be monitored according to a determination of moisture in the distillate by the Fischer method.
The process of vacuum evaporation of the condensate should be ended at a moisture content in the distillate from 2 to 4%.
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Literature cited
E. B. Hodge, French Patent No. 938,631 (1948).
R. Brunner and W. Friedrich, Austrian Patent No. 174,153 (1953).
D. M. Trakhtenberg, I. I. Inozemtseva, G. S. Rozenfel'd, et al., Antibiotiki, No. 8, 686 (1968).
N. Narosimhachari, G. Rao, and K. S. Santhanam, Curr. Sci.,34 (1965), p. 309.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 4, No, 8, pp. 26–30, August, 1970.
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Inozemtseva, I.I., Trakhtenberg, D.M. & Navol'neva, I.N. Investigation of the production of the potassium salt of benzylpenicillin. Pharm Chem J 4, 448–452 (1970). https://doi.org/10.1007/BF00771933
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DOI: https://doi.org/10.1007/BF00771933