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Transformation with SV40 virus prevents retinoic acid inhibition of plasma membrane NADH diferric transferrin reductase in rat liver cells

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Abstract

Retinoic acid inhibits the reduction of diferric transferrin through the transplasma membrane electron transport system on fetal rat liver cells infected with a temperature-sensitive SV40 virus when the cells are in the nontransformed state cultured at 40°C. When the cells are in the transformed state (grown at the permissive 33°C temperature), retinoic acid does not inhibit the diferric transferrin reduction. Inhibition of activity of nontransformed cells is specific for retinoic acid with only slight inhibition by retinol and retinyl acetate at higher concentrations. Isolated rat liver plasma membrane NADH diferric transferrin reductase is also inhibited by retinoic acid. The effect of transformation with SV40 virus to decrease susceptibility to retinoic acid inhibition stands in contrast to much greater adriamycin inhibition of diferric transferrin reduction in the transformed cells than in nontransformed cells.

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Authors and Affiliations

  1. Department of Biological Sciences, Purdue University, 47907, West Lafayette, Indiana

    I. L. Sun, W. Toole-Simms & F. L. Crane

  2. Department of Medicinal Chemistry, Purdue University, 47907, West Lafayette, Indiana

    D. J. Morré

  3. Department of Endocrinology, Karolinska Institute, Stockholm, Sweden

    H. Löw

  4. Human Genetics Branch, National Institute of Child Health and Human Development, 20205, Bethesda, Maryland

    J. Y. Chou

Authors
  1. I. L. Sun
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  2. W. Toole-Simms
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  3. F. L. Crane
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  4. D. J. Morré
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  5. H. Löw
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  6. J. Y. Chou
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Sun, I.L., Toole-Simms, W., Crane, F.L. et al. Transformation with SV40 virus prevents retinoic acid inhibition of plasma membrane NADH diferric transferrin reductase in rat liver cells. J Bioenerg Biomembr 20, 383–391 (1988). https://doi.org/10.1007/BF00769639

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  • DOI: https://doi.org/10.1007/BF00769639

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