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Synthesis and antibacterial activity of certain derivatives of 2-mercaptobenzothiazole

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Abstract

Five new 2,6-disubstituted derivatives of benzothiazole have been synthesized. The relation between the chemical structure and the biological activity of these compounds has been studied. It was found that the antimicrobial activity increases when sulfur in the number 2 position is oxidized to the sulfoxide and when the nitro group is introduced into the number 6 position in the corresponding sulfides. The preparations show no chemotherapeutic action in the animal body.

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Authors and Affiliations

  1. Institute of Pharmacology and Chemotherapy, Academy of Medical Sciences of the USSR, Moscow

    E. A. Kuznetsova, S. V. Zhuravlev, T. N. Stepanova, V. N. Solov'ev & V. S. Zueva

Authors
  1. E. A. Kuznetsova
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  2. S. V. Zhuravlev
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  3. T. N. Stepanova
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  4. V. N. Solov'ev
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  5. V. S. Zueva
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 2, pp. 7–10, February, 1967.

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Kuznetsova, E.A., Zhuravlev, S.V., Stepanova, T.N. et al. Synthesis and antibacterial activity of certain derivatives of 2-mercaptobenzothiazole. Pharm Chem J 1, 65–67 (1967). https://doi.org/10.1007/BF00768080

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  • DOI: https://doi.org/10.1007/BF00768080

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