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Synthesis and tuberculostatic activity of derivatives of 4-hydroxyquinazol-2-ylmercaptoacetic acid

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Conclusions

By condensing 2-mercaptoquinazol-4-one and its 6-methoxy derivative with monochloroacetic acid ethyl ester, the corresponding ethyl esters of the substituted mercapto-acetic acids were obtained. Amides, the hydrazide and hydrazones were obtained from the ethyl ester of 4-hydroxy-quinazol-2-ylmercaptoacetic acid. The compounds indicated possessed insignificant tuberculostatic activity.

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Literature cited

  1. K. M. Murav'eva et al., Khim. Farm. Zh., No. 8, 29 (1967).

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  2. M. S. Dhatt and K. S. Narang, J. Indian Chem. Soc.,31, 787 (1954

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Authors and Affiliations

  1. S. Ordzhonikidze All-Union Chemico-Pharmaceutical Scientific Research Institute, Moscow

    K. M. Murav'eva, N. V. Arkhangel'skaya, M. N. Shchukina, T. N. Zykova & G. N. Pershin

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  1. K. M. Murav'eva
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  2. N. V. Arkhangel'skaya
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  3. M. N. Shchukina
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  4. T. N. Zykova
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  5. G. N. Pershin
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Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 12, pp. 12–14, December, 1967.

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Murav'eva, K.M., Arkhangel'skaya, N.V., Shchukina, M.N. et al. Synthesis and tuberculostatic activity of derivatives of 4-hydroxyquinazol-2-ylmercaptoacetic acid. Pharm Chem J 1, 678–679 (1967). https://doi.org/10.1007/BF00761588

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  • DOI: https://doi.org/10.1007/BF00761588

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