Conclusion
The synthesis of a number of dialkylaminoalkyl esters and the corresponding amides of 4-phthalazone-1-carboxylic acids has been described. Some of these compounds possess local anaesthetic and short-term hypotensive activity.
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Literature cited
A. N. Kost and K. V. Grablyauskas, Khim. Farmats. Zh.,2, No. 8, 3 (1968).
H. J. Engelbrecht, D. Lenke, and H. Muller, German Federal Republic Patent No. 1046,626; Chem. Abstr.,55, 7447 (1961).
I. D. Lenke, Arzneimittel.-Forsch.,7, 678 (1957).
V. V. Zakusov, The Pharmacology of the Nervous System [in Russian], Leningrad (1953), p. 181.
A. N. Kost, Sh. Fel'deak, and K. V. Grablyauskas, Khim. Farmats. Zh.,1, No. 3, 43 (1967).
K. Nakajima, Nippon Kagaku Zasshi,81, 323 (1960).
M. Sarsunova, Pharmazie,18, 748 (1963).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 9, pp. 35–38, September, 1968.
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Grablyauskas, K.V., Rekhlyavichyus, V.Y., Grablyauskene, M.I. et al. Phthalazine and heterocycles related to it. Pharm Chem J 2, 506–509 (1968). https://doi.org/10.1007/BF00760739
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DOI: https://doi.org/10.1007/BF00760739