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Synthesis and antimicrobial action of α-(5-nitrofuryl-2)quinoxaline and its derivatives

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Conclusions

α-(5-Nitrofuryl-2) quinoxaline, and its α′-cyano- and α′-oxyderivative were synthesized by nitration of the respective furylquinoxalines with a nitrating mixture. When 2-oxy-3-(furyl-2) quinoxaline is subjected to nitration with excess of nitric acid a dinitro-derivative is formed which is presumably 6-nitro-3-(5-nitrofuryl-2)-2-oxyquinoxaline. The antibacterial, tuberculostatic, and fungistatic activities of the α-(furyl-2)- and α-(5-nitrofuryl-2) quinoxalines and their derivatives were studied “in vitro.”

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Authors and Affiliations

  1. Institute of Organic Synthesis, Academy of Sciences of the Latvian SSR, Riga

    N. O. Saldabol, L. N. Alekseeva, B. A. Brizga, A. Ya. Zile, L. V. Kruzmetra & K. K. Medne

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  1. N. O. Saldabol
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  2. L. N. Alekseeva
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  3. B. A. Brizga
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  4. A. Ya. Zile
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  5. L. V. Kruzmetra
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  6. K. K. Medne
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 10, pp. 14–17, October, 1968.

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Saldabol, N.O., Alekseeva, L.N., Brizga, B.A. et al. Synthesis and antimicrobial action of α-(5-nitrofuryl-2)quinoxaline and its derivatives. Pharm Chem J 2, 541–544 (1968). https://doi.org/10.1007/BF00759629

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  • DOI: https://doi.org/10.1007/BF00759629

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