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A study of lactams

XIII. An approach to the synthesis of 8-substituted-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidines from a lactim ether of 3-carbethoxy-2-piperidone

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Conclusion

N-Methyl-2-ethoxy-3-carbethoxy-1,4,5,6-tetrahydropyridine has been prepared by reaction of N-methyl-3-carbethoxy-2-piperidone with triethyloxonium fluoroborate with subsequent treatment of the intermediate complex with sodium ethoxide. In the case of condensation of the first compound mentioned above with compounds of the general formula R-C(=NH)NH2. which takes place with formation of 2-substituted-8-methyl-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidines, a method has been developed for introducing a substituent into the 8-position of tetrahydropyrido[2,3-d]pyrimidines.

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Authors and Affiliations

  1. S. Ordzhonikidze Moscow All-Union Pharmaceutical Chemistry Research Institute, USSR

    B. M. Pyatin & R. G. Glushkov

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  1. B. M. Pyatin
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  2. R. G. Glushkov
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Translated from Khimiko-Farmatsevticheskii Zhurnal, No. 10, pp. 11–13, October, 1968.

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Pyatin, B.M., Glushkov, R.G. A study of lactams. Pharm Chem J 2, 538–540 (1968). https://doi.org/10.1007/BF00759628

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  • DOI: https://doi.org/10.1007/BF00759628

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