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Synthesis of New Furo[2,3-b]pyridine and Furo[3,2-d]pyrimidine Derivatives

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Abstract

New furo[2,3-b]pyridine and pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine derivatives were synthesized from ethyl 5-alkyl-1-amino-6,7,8,9-tetrahydrofuro[2,3-c]isoquinoline-2-carboxylates. Reactions of ethyl 5-alkyl-1-[(aminoacetyl)amino]-6,7,8,9-tetrahydrofuro[2,3-c]isoquinoline-2-carboxylates with hydrazine hydrate in¬volved not only cyclization but also hydrazinolysis and elimination of the acyl group.

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Funding

This study was performed under financial support by the State Science Committee of the Ministry of Education and Science of Armenia in the framework of research project no. 18T-1D170.

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Authors and Affiliations

  1. Mnjoyan Institute of Fine Organic Chemistry, Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, Yerevan, Armenia

    S. N. Sirakanyan, E. K. Hakobyan & A. A. Hovakimyan

Authors
  1. S. N. Sirakanyan
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  2. E. K. Hakobyan
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  3. A. A. Hovakimyan
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Corresponding author

Correspondence to S. N. Sirakanyan.

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No conflict of interests is declared by the authors.

Additional information

Russian Text © The Author(s), 2019, published in Zhurnal Organicheskoi Khimii, 2019, Vol. 55, No. 9, pp. 1433–1439.

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Sirakanyan, S.N., Hakobyan, E.K. & Hovakimyan, A.A. Synthesis of New Furo[2,3-b]pyridine and Furo[3,2-d]pyrimidine Derivatives. Russ J Org Chem 55, 1344–1350 (2019). https://doi.org/10.1134/S1070428019090136

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  • DOI: https://doi.org/10.1134/S1070428019090136

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