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Isoquinoline derivatives

III. Synthesis of several 1-(4-alkoxybenzyl)-7-alkoxy-1,2,3,4-tetrahydroisoquinoline-4-spirocyclopentanes and their analogs

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

The corresponding amides were obtained by condensation of 1-(p-alkoxyphenyl)-1-aminomethylcyclopentanes with p-alkoxyphenylacetyl chlorides; the cyclization of the amides with subsequent reduction yielded 1-(4-alkoxybenzyl)-7-alkoxy-1,2,3,4- tetrahydroisoquinoline-4-spirocyclopentanes. The amides were converted to secondary amines by reduction. The IR and UV spectra of the intermediate and final compounds were studied. The purity of the compounds obtained was verified by chromatography.

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Literature cited

  1. A. L. Mndzhoyan, É. A. Markaryan, T. M. Martirosyan, and S. S. Vasilyan Khim. Geterotsikl. Soed., 529 (1969).

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Authors and Affiliations

  1. Institute of Fine Organic Chemistry, Academy of Sciences of the Armenian SSR, Erevan

    A. L. Mndzhoyan, É. A. Markaryan & T. M. Martirosyan

Authors
  1. A. L. Mndzhoyan
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  2. É. A. Markaryan
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  3. T. M. Martirosyan
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Additional information

For Communication II, see [2].

Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1381–1383, October, 1970.

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Mndzhoyan, A.L., Markaryan, É.A. & Martirosyan, T.M. Isoquinoline derivatives. Chem Heterocycl Compd 6, 1288–1290 (1970). https://doi.org/10.1007/BF00755079

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  • DOI: https://doi.org/10.1007/BF00755079

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