Summary
This work was undertaken to compare the intestinal GLI responses to oral glucose (1.75g/kg, 25% sol.), to a carbohydrate-rich meal (carbohydrate content about 1.75 g/kg) and to a protein meal (250–400 g grilled lean beef) in normal (n = 6) and gastrectomized (n = 6) subjects. As expected, after glucose administration the elevation of plasma GLI was more pronounced in the gastrectomy group (≃ 500% above baseline) than in the controls (≃ 75% above baseline). However, the gastrectomized patients responded to the carbohydrate meal with a very slight elevation of circulating GLI (≃ 45% above baseline), similar to that found in the controls (≃ 70% above baseline). After the protein meal, a small increase of GLI was also observed in both groups. — In conclusion, in gastrectomized subjects the ingestion of natural foodstuffs is followed by a normal elevation of plasma GLI, thereby suggesting the exclusion of this factor from involvement in the constellation of postgastrectomy syndrome. In these patients, the exaggerated rise in GLI after oral glucose is not representative of increments after physiological stimuli.
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Supported in part by a research grant (12-893-74) from the Instituto Nacional de Previsión, Spain, by a research contract (No. 1551/Rb) from the International Atomic Energy Agency, Vienna, Austria, and by a gift from the Alexander von Humboldt Stiftung, Bonn-Bad Godesberg, Federal Republic of Germany
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Marco, J., Hedo, J.A., Villanueva, M.L. et al. Effect of food ingestion on intestinal glucagon-like immunoreactivity (GLI) secretion in normal and gastrectomized subjects. Diabetologia 13, 131–135 (1977). https://doi.org/10.1007/BF00745140
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DOI: https://doi.org/10.1007/BF00745140