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Potenzierung der anorexigenen und psychomotorischen Wirkung von d-Amphetamin durch die Monoaminoxydasehemmer Iproniazid und Pivaloylbenzylhydrazin

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Summary

The anorexigenic and psychomotor stimulating effect of d-Amphetamine is shown to be potentiated by the Monoaminoxydase inhibitors Iproniazid and Pivaloylbenzylhydrazine in rats. The effect of Amphetamine and its potentiation by certain Monoaminoxydase inhibitors is discussed in connection with the following mechanisms:

  1. 1.

    Liberation of catecholamines at Amphetamine specific sites.

  2. 2.

    Direct effect of Amphetamine in the central nervous system in contrast to its peripheral effect.

  3. 3.

    Crossreacting effects of catecholamines and Amphetamine on their respective metabolism.

  4. 4.

    Inhibition of Amphetaminoxydase.

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  1. Aus dem Pharmakologischen Institut der Universität Zürich, Switzerland

    J. Spengler

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Herrn Prof. Dr.H. Fischer zum 70. Geburtstag gewidmet.

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Spengler, J. Potenzierung der anorexigenen und psychomotorischen Wirkung von d-Amphetamin durch die Monoaminoxydasehemmer Iproniazid und Pivaloylbenzylhydrazin. Naunyn - Schmiedebergs Arch 244, 153–160 (1962). https://doi.org/10.1007/BF00738221

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  • DOI: https://doi.org/10.1007/BF00738221

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