References
Rosenberg S.A. (1986). Adoptive immunotherapy of cancer using lymphokine-activated killer cells and interleukin-2 in V.T.DeVita, S.Hellman and S.A.Rosenberg (eds.), Important Advances in Oncology, J. B. Lippincott Company Publisher, Philadelphia, pp. 55–91.
Grimm E.A., Mazunider A., Zhang H.Z. and Rosenberg S.A. (1984). The lymphokine activated killer cell phenomenon: lysis of NK resistant fresh solid tumor cells by IL-2 activated autologous human peripheral blood lymphocytes. J. Exp. Med. 155, 1823–1841.
Rosenberg S.A., Lotze M.T., Muul L.M. (1987). A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone. N. Engl. J. Med. 316, 889–897.
Lotze M.T., Matori Y.L., Ettinghausen S.E., Rajner A.A., Sharrow S.O., Seipp C.A., Custer M.C. and Rosenberg S.A. (1985). In vivo administration of peripheral human interleukin-2. J. Immunol. 135, 2865–2875.
Ettinghausen S.E., Moore J.G., White D.E. and Rosenberg S.A. (1987). Hematological effects of immunotherapy with lymphokine-activated killer cells and recombinant interleukin-2 in cancer patients. Blood 69, 1654–1660.
Tritarelli E., Rocca E., Testa U., Boccoli G., Camagna A., Calabresi F. and Peschle C. (1990). Adoptive immunotherapy with high-dose interleukin-2: kinetics of circulating progenitors correlate with IL-6, G-CSF levels. Blood (in press).
Mier J.K., Vachino G., Van DerHeer J.W., Numerof R.P., Adams S., Cannon J.G., Beinheon H.A., Atkins M.B., Parkinson D.R., Dinarello C.A. (1988). Induction of circulating tumor necrosis factor (TNF-alpha) as the mechanism for the febrile response to interleukin-2 in cancer patients. J. Clin. Immunol. 8: 426–436.
Boccoli G., Masciulli R., Ruggeri E.M., Carlini P., Giannella G., Montesoro E., Isacchi G., Testa U., Calabresi F., Peschle C. (1990). Adoptive immunotherapy of human cancer: the cytokine cascade and monocyte activation following high-dose interleukin-2 bolus treatment. Cancer Res. 50: 5795–5800.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Testa, U., Bulgarini, D., Montesoro, E. et al. IL-2 induces the release of secondary cytokines which stimulate the cytotoxic activity of either NK or CD8+ lymphocytes. Cytotechnology 5 (Suppl 1), 126–129 (1991). https://doi.org/10.1007/BF00736828
Issue Date:
DOI: https://doi.org/10.1007/BF00736828