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Ethnic differences in the expression of blood group antigens in the salivary gland secretory cells from German and Japanese non-secretor individuals

  • Glycoconjugate Journal
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Abstract

Type 1 ABO blood group antigens (peripheral core structure: Galβ1-3GlcNAcβ1-R) are expressed mainly in endodermally-derived tissues, but are not synthesized in mesodermally-derived tissues. In the former tissues, H type 1 antigen is generated largely by α-2-l-fucosyltransferase encoded by secretor (Se) gene and acting on the terminal galactose of the type 1 precursor chain. This theory has been generally accepted, and it seems that the expression of ABO blood group antigens is absent, or expressed at a low level, in these tissues from non-secretor individuals. In this immunohistochemical study on the secretory cells of salivary glands, we found ethnic difference between German and Japanese non-secretor individuals in the expression of blood group antigens: i.e. the expression of the type 1 blood group antigens is present in these cells from Japanese non-secretor individuals but absent from German. A possible explanation is that another α-2-l-fucosyltransferase, independent of the secretor gene, is present in Japanese non-secretor individuals.

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References

  1. Ito N, Nishi K, Kawahara S, Okamura Y, Hirota T, Rand S, Fechner G, Brinkmann B (1990)Histochem J 22: 604–14.

    Google Scholar 

  2. Wang B, Akiyama K, Jia JT, Kimura H (1994)Forensic Sci Int 67: 1–8.

    Google Scholar 

  3. Gibbs MB, Akeroyd JH, Zapf JJ (1961)Nature 192: 1196–97.

    Google Scholar 

  4. Henry SM, Oriol R, Samuelsson BE (1994)Glycoconjugate J 11: 593–99.

    Google Scholar 

  5. Ito N, Nishi K, Nakajima M, Matsuda Y, Ishitani A, Mizumoto J, Hirota T (1986)Acta Histochem Cytochem 19: 205–18.

    Google Scholar 

  6. Ito N, Nishi K, Nakajima M, Ishitani A, Okamura Y, Matsuda Y, Hirota T (1987)J Histochem Cytochem 35: 881–90.

    Google Scholar 

  7. Nishi K, Fechner G, Rand S, Brinkmann B (1989)Z Rechtsmed 102: 255–62.

    Google Scholar 

  8. Ito N, Nishi K, Nakajima M, Okamura Y, Hirota T (1988)J Histochem Cytochem 36: 503–9.

    Google Scholar 

  9. Hakomori S (1981)Semin Hematol 18: 39–62.

    Google Scholar 

  10. Baker DA, Sugii S, Kabat EA, Ratcliffe RM, Hermentin P, Lemieux RU (1983)Biochemistry 22: 2741–50.

    Google Scholar 

  11. Breimer ME, Samuelsson BE (1986)Transplantation 42: 88–90.

    Google Scholar 

  12. Mollicone R, Dalix AM, Jacobsson A, Samuelsson BE, Gerard G, Crainic K, Caillard T, Le Pendu J, Oriol R (1988)Glycoconjugate J 5: 499–512.

    Google Scholar 

  13. Hindsgaul O, Khare DP, Bach M, Lemieux RU (1984)Can J Chem 63: 2653–58.

    Google Scholar 

  14. Henry SM, Simpson LA, Woodfield DG (1988)Hum Hered 38: 111–16.

    Google Scholar 

  15. Henry SM, Benny AG, Woodfield DG (1990)Vox Sang 58: 61–66.

    Google Scholar 

  16. Lin-Chu M, Broadberry RE, Chang FJ (1988)Transfusion 28: 350–52.

    Google Scholar 

  17. Mourant AE, Kopec A, Domaniewska-Sobczak K (1976) InThe Distribution of the Human Blood Groups and Other Polymorphisms, 2nd ed., pp. 548–76. Oxford: Oxford University Press.

    Google Scholar 

  18. Oriol R, Danilovs J, Hawkins BR (1981)Am J Hum Genet 33: 421–31.

    Google Scholar 

  19. Betteridge A, Watkins WM (1985)Glycoconjugate J 2: 61–78.

    Google Scholar 

  20. Betteridge A, Watkins WM (1985)Biochem Soc Trans 13: 1126–27.

    Google Scholar 

  21. Kumazaki T, Yoshida A (1984)Proc Natl Acad Sci USA 81: 4193–97.

    Google Scholar 

  22. Schenkel-Brunner H, Chester MA, Watkins WM (1972)Eur J Biochem 30: 269–77.

    Google Scholar 

  23. Kyprianou P, Betteridge A, Donald AS, Watkins WM (1990)Glycoconjugate J 7: 573–88.

    Google Scholar 

  24. Dabelsteen E, Vedtofte P, Hakomori SI, Young WW (1982)J Invest Dermatol 79: 3–7.

    Google Scholar 

  25. Oriol R, Le Pendu J, Mollicone R (1986)Vox Sang 51: 161–71.

    Google Scholar 

  26. Breimer ME (1984)Arch Biochem Biophys 228: 71–85.

    Google Scholar 

  27. Dabelsteen E, Graem N, Clausen H, Hakomori S (1988)Cancer Res 48: 181–87.

    Google Scholar 

  28. Blaszczyk-Thurin M, Sarnesto A, Thurin J, Hindsgaul O, Koprowski H (1988)Biochem Biophys Res Commun 151: 100–8.

    Google Scholar 

  29. Larsen RD, Ernst LK, Nair RP, Lowe JB (1990)Proc Natl Acad Sci USA 87: 6674–78.

    Google Scholar 

  30. Kelly RJ, Ernst LK, Larsen RD, Bryant JG, Robinson JS, Lowe JB (1994)Proc Natl Acad Sci USA 91: 5843–47.

    Google Scholar 

  31. Rouquier S, Lowe JB, Kelly RB, Fertitta AL, Lennon GG, Giorgi D (1995)J Biol Chem 270: 4632–39.

    Google Scholar 

  32. Kelly RB, Rouquier S, Giorgi D, Lennon GG, Lowe JB (1995)J Biol Chem 270: 4640–49.

    Google Scholar 

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Authors and Affiliations

  1. Department of Legal Medicine, Shiga University of Medical Science, Seta Tsukinowa-cho, 520-21, Otsu, Shiga, Japan

    Akio Tanegashima & Katsuji Nishi

  2. Department of Legal Medicine, Mie University School of Medicine, 2-174, Edobashi, 514, Tsu, Mie, Japan

    Akio Tanegashima & Tatsushige Fukunaga

  3. Institüt für Rechtsmedizin der Universität Münster, Von-Esmarch Straβe 86, D-48149, Münster, BRD

    Steven Rand & Bernd Brinkmann

Authors
  1. Akio Tanegashima
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  2. Katsuji Nishi
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  3. Tatsushige Fukunaga
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  4. Steven Rand
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  5. Bernd Brinkmann
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Tanegashima, A., Nishi, K., Fukunaga, T. et al. Ethnic differences in the expression of blood group antigens in the salivary gland secretory cells from German and Japanese non-secretor individuals. Glycoconjugate J 13, 537–545 (1996). https://doi.org/10.1007/BF00731441

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  • DOI: https://doi.org/10.1007/BF00731441

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