Abstract
Although the pathogenesis of primary Sjögren’s syndrome (pSS) is still not fully unraveled, new critical insights have been made in recent years. To date, there is burgeoning evidence indicating that pSS represents a multifactorial disease in which the interaction between genetic and environmental factors are thought to play a role. In this second part on the pathogenesis of Sjögren’s syndrome, the function of characteristic cytokines and chemokines and their expression by cells of the innate and adaptive immune systems are put into context with pathophysiological processes. Patients with pSS demonstrate an upregulation of type 1 interferon-inducible genes in salivary glands and peripheral blood cells. Also, the microenvironment of salivary gland epithelial cells will be reviewed.
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Finzel, S., Voll, R.E. (2022). On the Complex Pathogenesis of Sjögren’s Syndrome: Salivary Gland Epithelial Cells and Cells of the Innate and Adaptive Immune System. In: Bruyn, G.A.W. (eds) Sjögren’s Syndrome and the Salivary Glands. Contemporary Rheumatology. Springer, Cham. https://doi.org/10.1007/978-3-030-90977-2_6
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