Summary
The fine structure of a dysplastic gangliocytoma of the cerebellum is studied by means of the Golgi method and electron microscopic examination.
Thick proximally unbranched dendrites with terminal arborizations and varicose influorescences in the form of a basket are stained with the Golgi method. Axons are always descendant to the inner myelinated layer of the redistributed cerebellar cortex, while ascendant collaterals are observed at the level of the outer myelinated layer.
Clear and dense-core vesicles and synapses are common in the cellular profiles under electron microscopic examination. From these data and because of the lack of putative connections through the white matter, an organized, self-regulated, catecholamine-mediated complex may be postulated.
References
Ambler, M., Pogacar, S., Sidman, R.: Lhermitte-Duclos disease (Granule cell hypertrophy of the cerebellum). Pathological analysis of the first familial cases. J. Neuropathol. Exp. Neurol.28, 622–647 (1969)
Azzarelli, B., Richards, D. E., Anton, A. H., Roessman, V.: Central neuroblastoma. Electron microscopic observations and catecholamine determinations. J. Neuropathol. Exp. Neurol.36, 384–397 (1977)
Ferrer, I., Fernandez-Alvarez, E.: Lisencefalia: Agiria. Un estudio con el método de Golgi. J. Neurol. Sci.34, 109–120 (1977) (Spanish)
Greenberg, R., Rosenthal, I., Falk, G. S.: Electron microscopy of tumours secreting catecholamines: correlations with biochemical data. J. Neuropathol. Exp. Neurol.28, 475–500 (1969)
Hadfield, M. G., Silverberg, S. G.: Light and electron microscopy of giant-cell glioblastoma. Cancer30, 989–996 (1977)
Lentz, T. L.: Fine structure of nerves in the regenerating limb of the newt triturus. Am. J. Anat.121, 647–670 (1967)
Misugi, K., Misugi, N., Newton, W. A.: Fine structural study of neuroblastoma, ganglioneuroblastoma, and pheochromocytoma. Arch. Pathol.86, 160–169 (1968)
Palay, S., Chan Palay, V.: Cerebellar cortex. Cytology and organization. Berlin, Heidelberg, New York: Springer 1974
Polivshock, J. T.: The fine structure of the axons and growth cones of the human fetal cerebral cortex. Brain Res.114, 379–389 (1976)
Rakic, P.: Role of cell interaction in development of dendritic patterns. In: Advances in neurology, Vol. 12, pp. 117–134. Kreutzberg, G. W. (ed.) New York: Raven Press 1975
Ramón y Cajal, S.: Histologie du système nerveux de l'homme et des vertébrés. 2ème reimpr. pp. 433–434. Madrid: Consejo Superior de Investigaciones Cientificas 1972
Roberston, D. M., Hendry, W. S., Vogel, F. S.: Central Ganglioneuroma: a case study using electron microscopy. J. Neuropathol. Exp. Neurol.23, 692–705 (1964)
Rubinstein, L. J.: Dysplastic gangliocytoma of the cerebellum. In: Tumors of the central nervous system, pp. 164–167. Washington: AFIP 1972
Rubinstein, L. J., Hermann, H. M.: A light and electronmicroscopic study of temporal lobe ganglioglioma. J. Neurol. Sci.16, 27–48 (1972)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ferrer, I., Isamat, F. & Acebes, J. A golgi and electron microscopic study of a dysplastic gangliocytoma of the cerebellum. Acta Neuropathol 47, 163–165 (1979). https://doi.org/10.1007/BF00717043
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00717043