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Acta Neuropathologica

, Volume 83, Issue 4, pp 434–439 | Cite as

Binswanger's disease in the absence of chronic arterial hypertension

A case report with clinical, radiological and immunohistochemical observations on intracerebral blood vessels
  • K. -C. Ma
  • P. O. Lundberg
  • A. Lilja
  • Y. Olsson
Case Reports

Summary

The cerebral changes are described in a woman of 54 who suffered from Binswanger's encephalopathy: there were no signs or symptoms of chronic arterial hypertension. The disease presented as dementia of about 3 years duration. Computed tomography of the brain 2. 5 years before her death showed bilateral widespread hypodense lesions in the cerebral white matter. She died of an asthmatic attack. Autopsy disclosed extensive bilateral degeneration of the central white matter, lacunes and gliosis. Severe obliterative arteriolosclerosis occurred in the meningeal vessels and those supplying the affected parts of the brain. Light microscopy showed that the most severe lesions occurred in the arterioles. Immunohistochemistry demonstrated profound extravasation of plasma proteins chiefly albumin, indicating dysfunction of the blood-brain barrier. Thus, the lesions characteristic of Binswanger's encephalopathy may develop in the absence of chronic arterial hypertension. Additional pathogenic factors, possibly genetic predisposition to vascular injury may play a role in the development of this condition.

Key words

Binswanger's disease White matter lesion Arteriolosclerosis Dementia 

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • K. -C. Ma
    • 1
  • P. O. Lundberg
    • 2
  • A. Lilja
    • 3
  • Y. Olsson
    • 1
  1. 1.Laboratory of Neuropathology, Institute of PathologyUniversity HospitalUppsalaSweden
  2. 2.Department of NeurologyUniversity HospitalUppsalaSweden
  3. 3.Department of Diagnostic RadiologyUniversity HospitalUppsalaSweden

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