Summary
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1.
Effects of bath-applied recombinant human interleukin-1 (rhIL-1) and interleukin-2 (rhIL-2) on the acetylcholine (ACh)-induced K+ current recorded from identified neurons (R9 and R10) ofAplysia kurodai were investigated with voltage-clamp and pressure ejection techniques.
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2.
Bath-applied rhIL-1 and rhIL-2 (10–40 U/ml) reduced the ACh-induced current in the neurons without affecting the resting membrane conductance and holding current.
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The suppressing effects of these cytokines on the current were completely reversible.
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4.
Heat-inactivated rhIL-1 and rhIL-2 were without effect.
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5.
These results suggest that the immunomodulators, IL-1 and IL-2, can modulate the ACh-induced response in the nervous system.
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Sawada, M., Hara, N. & Maeno, T. Reduction of the acetylcholine-induced K+ current in identifiedAplysia neurons by human interleukin-1 and interleukin-2. Cell Mol Neurobiol 12, 439–445 (1992). https://doi.org/10.1007/BF00711544
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DOI: https://doi.org/10.1007/BF00711544