Abstract
Debenzylation by catalytic transfer hydrogenation (CTH) of various organic compounds is a simple, fast, and safe method. Though CTH is widely used in reductions, only few data are available for the conversion of azides to amines. The number of usable transfer compounds is limited in cases of sugar derivatives, as the most common transfer materials, e.g. hydrazine hydrate or formic acid, can compete in side-reactions. The present study explores the limits of the reaction parameters and transfer compounds.
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Dedicated to Professor József Szejtli.
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Jicsinszky, L. Catalytic transfer hydrogenation of cyclodextrin azides and benzylated glucose derivatives. J Incl Phenom Macrocycl Chem 18, 247–254 (1994). https://doi.org/10.1007/BF00708731
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DOI: https://doi.org/10.1007/BF00708731