Abstract
Studies by electron paramagnetic resonance (EPR), differential scanning calorimetry, thermogravimetric analysis, HPLC and NMR showed that radicals produced by thermolysis and photolysis of benzoyl peroxide,t-butyl peroxide and cumene hydroperoxide included inβ-cyclodextrin (β-CD), undergo significant reaction with theβ-CD. The formation ofβ-CD radicals was observed by EPR. Products formed by addition of radicals toβ-CD were also observed. Such host:guest radical reactions explain the reported stabilization of peroxides, found withβ-CD inclusion, as being primarily due to the interruption of chain reactions by trapping of the chain carriers. A small increase in activation barrier for cleavage of the included peroxide inβ-CD was also observed.
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Lehmann, M.N., Bakker, M.G., Patel, H. et al. The effect of inclusion inβ-cyclodextrin on the chemistry of peroxides: Reactions of radicals withβ-cyclodextrin. J Incl Phenom Macrocycl Chem 23, 99–117 (1995). https://doi.org/10.1007/BF00707888
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DOI: https://doi.org/10.1007/BF00707888