Abstract
Nivalenol is a toxic trichothecene metabolite which is produced by a number of differentFusarium species. However, the nature of its immediate biosynthetic precursor is not known. Oxidation of 7-deoxynivalenol(3α,4β, 15-trihydroxy-12,13-epoxytrichothec-9-ene-8-one) to nivalenol occurred with reagents known to react by a free radical pathway, such as hydrogen peroxide-ferrous ion-ascorbic acid or lead tetracetate, but not with electrophilic reagents requiring prior formation of the enol. These results suggest that 7-deoxynivalenol or an acetylated derivative could be the biosynthetic precursor of nivalenol.
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Ehrlich, K.C. Preparation of theFusarium toxin, nivalenol, by oxidation of the putative biosynthetic precursor, 7-deoxynivalenol. Mycopathologia 107, 111–114 (1989). https://doi.org/10.1007/BF00707546
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DOI: https://doi.org/10.1007/BF00707546