Summary
Ultrastructural examination of the antral G cells has been carried out on 11 patients with chronic duodenal ulcer, before and after treatment with a histamine H-2 - receptor antagonist (cimetidine 1 g/ day) for 8 weeks. The study demonstrated an increased area of the Golgi complex, rough endoplasmic reticulum and electron-dense granules, indicating increased G cell activity during treatment. An increased number of lysosomes was a constant feature during treatment. As an hypothesis we suggest that these lysosomes may participate in the secretory mechanism of human G cells, by destroying superfluous (Gastrin) components produced during hyperactivity.
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Nielsen, H.O., Hage, E. The antral gastrin-producing cells in duodenal ulcer patients. Vichows Archiv A Pathol Anat 406, 271–277 (1985). https://doi.org/10.1007/BF00704296
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DOI: https://doi.org/10.1007/BF00704296