Summary
Three morphologically distinct kinds of cytoplasmic inclusion (lamellar, reticular and crystalloid) developed in the retinal cells of suckling rats treated with Pexid (300 mg/kg/day). Lamellar inclusions were most abundant and they were seen in all types of retinal cells. This variety of inclusion was especially numerous in the ganglion cells. Reticular inclusions were encountered less commonly than the lamellar type and their distribution did not show any particular cellular predilection. Crystalloid inclusions were observed only in the pigment epithelial cells. The mechanism of formation of the three types of inclusion is not known, nor is the reason why certain types of inclusion occur most commonly in a particular kind of cell. One can speculate, however, that the dissimilarity of form may reflect differences in the metabolism and physicochemical properties of the various retinal cells.
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Abraham, R., Hendy, R. J.: Irreversible lysosomal damage induced by chloroquine in the retinae of pigmented and albino rats. Exp. Mol. Pathol.12, 185–200 (1970)
Anzil, A. P., Herrlinger, H., Blinzinger, K.: Lipidose des Nervensystems nach Chlorphentermin-Applikation. Naturwissenschaften61, 35–36 (1974)
Arai, K., Yates, R. D., Rapport, D. A.: Fine structure and chemical composition of opaque cytoplamic bodies of triparanol treated syrian hamsters. II. Phospholipid analysis of opaque bodies from adrenal glands. Tex. Rep. Biol. Med.25, 250–359 (1967)
Bockhardt, H., Drenckhahn, D., Lüllmann, R.: Amiodarone-induced lipidosis-like alterations in ocular tissues of rats. Albrecht von Graefes Arch. Klin. Ophthalmol.207, 91–96 (1978)
Chen, I. L., Yates, R. D.: An ultrastructural study of opaque cytoplasmic inclusions induced by triparanol treatment. Am. J. Anat.121, 705–725 (1967)
Drenkhahn, D., Lüllmann-Rauch, R.: Drug induced retinal lipidosis: differential susceptibilities of pigment epithelium and neuroretinal toward several amphiphilic cationic drugs. Exp. Mol. Pathol.28, 360–371 (1978)
Fedorko, M. D.: Effects of chloroquine of morphology of leukocytes and pancreatic exocrine cells from the rat. Lab. Invest.18, 27–37 (1968)
Howell, J. I., Fisher, D., Goodall, A. H., Verrinder, M., Lucy, J. A.: Interactions of membrane phospholipids with fusogenic lipids. Biochem. Biophys. Acta332, 1–10 (1973)
Jung, H. J., Suzuki, K.: Morphological changes in CNS of rats treated with perhexiline maleate (pexid). Acta Neuropathol. (Berl.)42, 159–164 (1978)
Junger, E., Reinauer, H.: Liquid crystalline phases of hydrated phosphatidyl ethanolamine. Biochem. Biophys. Acta183, 304–308 (1969)
Lüllmann-Rauch, R.: Retinal lesions in rats after treatment with chlorphentermine or with tricyclic antidepressants. Virchows Archiv [Cell Pathol]15, 309–312 (1974)
Lüllmann-Rauch, R.: Retinal lipidosis in albino rats treated with chlorphentermine and with tricyclic antidepressants. Acta Neuropathol. (Berl.)35, 55–67 (1976)
Mussini, J. M., Hauw, J. J. Escourolle, R.: Étude en microscopie électronique des lésions nerveuses musculaires et cutanées déermińes par le maléate de perhexiline. Acta Neuropathol. (Berl.)38, 53–59 (1977)
Sakuragawa, M.: Niemann-pick disease-like inclusions caused by a hypocholesteremic agent. Invest. Ophthalmol. Visual Sci.15, 1022–1027 (1976)
Schutta, H. S., Neville, H. E.: Effects of cholesterol synthesis inhibitors on the nervous system. Lab. Invest.19, 487–493 (1968)
Suzuki, K., Zagoren, J. C., Gonatas, J., Suzuki, K.: Ultrastructural study of neuronal cytoplasmic inclusions produced by hypochole-sterolemic drug AY9944. Acta. Neuropathol. (Berl.)26, 185–197 (1973)
Suzuki, K., Zagoren, J. C., Chen, S. M., Suzuki, K.: Effect of triparanol and 20,25-diazacholesterol in CNS of rats; morphological and biochemical studies. Acta Neuropathol. (Berl.)29, 141–150 (1974)
Suzuki, K., Zagoren, J. C.: Lesions in central nervous system of rats treated with hypocholesterolemic drugs. VII. International congress of neuropathology, pp. 387–389. Amsterdam: Excerpta Medica 1975
Winsor, T.: Clinical evaluation of perhexiline maleate. Clin. Pharmacol. Ther.71, 85–89 (1970)
Yates, R. D.: The effects of triparanol on adrenocortical cells of the zona fasciculata of Syrian hamsters. Z. Zellforsch.71, 41–52 (1966)
Young, R. W., Bok, D.: Participation of the retinal pigment epithelium in the rod outer segment renewal process. J. Cell Biol.42, 392–403 (1969)
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Jung, H.J., Weisenfreund, J., Willson, N.J. et al. Pexid-induced rat retinal pathology. Acta Neuropathol 47, 33–37 (1979). https://doi.org/10.1007/BF00698270
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DOI: https://doi.org/10.1007/BF00698270