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Die Funktion der Nebennieren männlicherTupaia belangeri

Nebennierengewicht, Ascorbinsäure und Glucocorticoide im Blut bei kurzem und bei andauerndem soziopsychischem Stress

Adrenal function in maleTupaia belangeri

Adrenal weight, ascorbic acid and glucocorticoid concentration in the blood after short and prolonged psychosocial stress

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Literatur

  • Autrum, H., Holst, D. v.: Sozialer „Stress” bei Tupajas (Tupaia glis) und seine Wirkung auf Wachstum, Körpergewicht und Fortpflanzung. Z. vergl. Physiol.58, 347–355 (1968).

    Google Scholar 

  • Bahn, R. C., Glick, D.: Studies in histochemistry: effects of stress conditions, ACTH, cortisone and desoxycorticosterone on the quantitative histological distribution of ascorbic acid in adrenal glands of the rat and monkey. Endocrinology54, 672–684 (1954).

    Google Scholar 

  • Bajusz, E.: The pituitary-adrenocortical system, its regulation and adaptive functions. In: Physiology and pathology of adaptation mechanisms (ed. E. Bajusz), p. 89–145. Oxford-London-New York: Pergamon Press 1969.

    Google Scholar 

  • Barrett, A. M., Hodges, J. R.: The effect of stress on the level of adrenocorticotrophin in the plasma of normal and adrenalectomized rats. J. Endocr.14, 292–296 (1956).

    Google Scholar 

  • Bartlett, R. G., Jr., Miller, M. A.: The adrenal cortex in restraint hypothermia and in adaptation to the stress of restraint. J. Endocr.14, 181–187 (1956).

    Google Scholar 

  • Berliner, D. L., Keller, N., Dougherty, T. F.: Mediated and direct effects of ACTH and corticosteroids in stress. In: Physiology and pathology of adaptation mechanisms (ed. E. Bajusz), p. 204–213. Oxford-London-New York: Pergamon Press 1969.

    Google Scholar 

  • Christian, J. J.: Endocrine adaptive mechanisms and the physiologic regulation of population growth. In: Physiological mammalogy, vol. 1, Mammalian populations (eds. W. V. Mayer and R. G. van Gelder), p. 189–353. New York and London: Academic Press 1963.

    Google Scholar 

  • Clayton, B. E., Prunty, F. T. G.: Relation of adrenal cortical function to scurvy in guinea pigs. Brit. med. J.2, 927–930 (1951).

    Google Scholar 

  • Davis, W. W., Garren, L. D.: Evidence for the stimulation by adrenocorticotropic hormone of the conversion of cholesterol esters to cholesterol in the adrenal, in vivo. Biochem. biophys. Res. Commun.24, 805–810 (1966).

    Google Scholar 

  • Eguchi, Y.: Interrelationships between the fetal and maternal hypophysealadrenal axis in rats and mice. In: Physiology and pathology of adaptation mechanisms (ed. E. Bajusz), p. 3–27. Oxford-London-New York: Pergamon Press 1969.

    Google Scholar 

  • Elton, R. L., Zarrow, I. G., Zarrow, M. X.: Depletion of adrenal ascorbic acid and cholesterol: a comparative study. Endocrinology65, 152–157 (1959).

    Google Scholar 

  • Eränkö, O.: Short-term effects of potassium, sodium and ACTH on the histochemistry of the adrenal glands of the rat. Acta endocr. (Kbh.)18, 189–200 (1955).

    Google Scholar 

  • Fisher, J. D., Salva, S. J. de: Plasma corticosterone and adrenal ascorbic acid levels in adreno- and neurohypophysectomized rats given epinephrine postoperatively. Amer. J. Physiol.197, 1263–1264 (1959).

    Google Scholar 

  • Fortier, C.: Adrenohypophysis and adrenal cortex. Ann. Rev. Physiol.24, 223–258 (1962).

    Google Scholar 

  • Ganong, W. F.: Adrenal-hypophyseal interrelations. In: Comparative endocrinology (ed. A. Gorbman), p. 187–201. New York: Wiley 1959.

    Google Scholar 

  • Glick, D., Redlich, D. V., Levine, S.: Fluorometric determination of corticosterone and cortisol in 0.02–0.05 milliliters of plasma or submilligram samples of adrenal tissue. Endocrinology74, 653–655 (1964).

    Google Scholar 

  • Graef, V., Staudinger, H.: Untersuchungen zur Spezifität der fluorometrischen Bestimmung der 11-Hydroxycorticosteroide im Plasma. Z. klin. Chem.8, 368–373 (1970).

    Google Scholar 

  • Griffiths, M. E., Calaby, J. H., McIntosh, D. L.: The stress syndrome in the rabbit. C.S.I.R.O.Wildl. Res.5, 134–148 (1960).

    Google Scholar 

  • Grosu, L., Derevenco, P., Derevenco, V.: Die Wirkung des Bradykinins auf die Aktivierung der Sekretion von adrenooorticotropem Hormon. Stud. Cercet. Fiziol.10, 357–363 (1965).

    Google Scholar 

  • Haltmeyer, G. C., Denenberg, V. H., Thatcher, J., Zarrow, M. X.: Response of the adrenal cortex of the neonatal rat after subjection to stress. Nature (Lond.)212, 1371 (1966).

    Google Scholar 

  • Harding, B. W., Bell, J. J., Oldham, S. B., Wilson, L. D.: Corticoid biosynthesis in adrenal cortical mitochondria. In: Functions of the adrenal cortex (ed. K. W. McKeras), p. 831–896. Amsterdam: North Holland Publ. Co, 1968.

    Google Scholar 

  • Harding, B. W., Nelson, D. H.: Changes in rat adrenal ascorbic acid and glutathione following hypophysectomy and ACTH stimulation. Endocrinology73, 97–102 (1963).

    Google Scholar 

  • Hedner, P., Rerup, C.: Plasma corticosteroid levels and adrenal ascorbic acid after intravenous corticotrophin injections and “stressful” stimuli in the rat. Acta endocr. (Kbh.)39, 527–538 (1962a).

    Google Scholar 

  • Hedner, P., Rerup, C.: Adrenocortical activity following corticotrophin injection at low ascorbic acid levels. Acta endocr. (Kbh.)41, 219–226 (1962b).

    Google Scholar 

  • Holst, D. v.: Sozialer Stress bei Tupajas (Tupaia belangeri). Die Aktivierung des sympathischen Nervensystems und ihre Beziehung zu hormonal ausgelösten ethologischen und physiologischen Veränderungen. Z. vergl. Physiol.63, 1–58 (1969).

    Google Scholar 

  • Holst, D. v.: Die Nebenniere vonTupaia belangeri. J. comp. Physiol.78, 274–288 (1972a).

    Google Scholar 

  • Holst, D. v.: Renal failure as the cause of death inTupaia belangeri exposed to persistent social stress. J. comp. Physiol.78, 236–273 (1972b)

    Google Scholar 

  • Jones, R. S., Peric-Golia, L., Eik-Nes, K.: Ascorbic acid deficiency and adrenocortical function in the guinea pig. Endocrinology63, 659–668 (1958).

    Google Scholar 

  • Jurtshuk, P, Jr., Weltman, A. S., Sackler, A. M.: Biochemical responses of rats to auditory stress. Science129, 1424–1425 (1959).

    Google Scholar 

  • Kersten, H., Kersten, W., Staudinger, H.: Zum Wirkungsmechanismus der Ascorbinsäure. I. Isolierung einer Ascorbinsäureabhängigen DPNH-Oxydase aus Nebennierenmikrosomen. Biochim. biophys. Acta (Amst.)27, 598–608 (1958).

    Google Scholar 

  • Kitabchi, A. E.: Ascorbic acid in steroidogenesis. Nature (Lond.)215, 1385–1386 (1967).

    Google Scholar 

  • Koritz, S. B.: The inhibition of DPNH of the transformation of pregnenolone to progesterone by a rat adrenal preparation. Arch. Biochem.100, 349–352 (1963).

    Google Scholar 

  • Lahiri, S., Lloyd, B. B.: The form of vitamin C released by the rat adrenal. Biochem. J.84, 474–477 (1962).

    Google Scholar 

  • Long, C. N. H.: The relation of cholesterol and ascorbic acid to the secretion of the adrenal cortex. Recent Progr. Hormone Res.1, 99–122 (1947).

    Google Scholar 

  • Mattingly, D.: A simple fluorimetric method for the estimation of free 11-hydrocorticoids in human plasma. J. clin. Path.15, 374–379 (1962).

    Google Scholar 

  • Milković, K., Milkoviç, S.: Reactiveness of the pituitary-adrenal system immediately after birth in some laboratory mammals. Proc. 15th int. Congr. Zool., London: 995–997 (1959).

  • Milković, K., Milković, S.: Functioning of the pituitary-adrenocortical axis in rats at and after birth. Endocrinology73, 535–539 (1963).

    Google Scholar 

  • Milković, K., Milković, S.: Adrenocorticotropic hormone secretion in the fetus and infant. In: Neuroendocrinology, vol. 1 (eds. L. Martini, and W. F. Ganong), p. 371–405. New York and London: Academic Press 1966.

    Google Scholar 

  • Nowell, N. W.: Studies in the activation and inhibition of adrenocorticotrophin secretion. Endocrinology64, 191–201 (1959).

    Google Scholar 

  • Nyakas, C., Endröczi, E.: Activation of pituitary-adrenocortical function by conditioned fear in infant and adult rats. Acta physiol. acad. sci. hung.36, 401–405 (1969).

    Google Scholar 

  • Pace, N., Schaffer, F. L., Elmadjian, F., Minard, D., Davis, S. W., Kilbuck, J. D., Walker, E. L., Johnston, M. E., Zilinsky, A., Gerard, R. W., Forsham, P. H., Taylor, J. G.: Physiological studies on infantry men in combat. Univ. Calif. Publ. Physiol.10, 1–47 (1956).

    Google Scholar 

  • Pegelman, S. G., Kanarik, U. K.: Adaptive responses in guinea pigs under conditions of a prolonged cooling. Sechenov physiol. J. U.S.S.R.53, 1212–1217 (1967).

    Google Scholar 

  • Pfleiderer, G.: Glykogen. Bestimmung als D-Glucose mit Hexokinase, Pyruvatkinase und Lactat-Dehydrogenase. In: Methoden der enzymatischen Analyse (Hrsg. H. Bergmeyer), S. 59–62. Weinheim. Verlag Chemie 1962.

    Google Scholar 

  • Rerup, C., Hedner, P.: On the assay of corticotrophin: comparison of the plasma corticosteroid and adrenal acid response. Acta endocr. (Kbh.)38, 220–235 (1961).

    Google Scholar 

  • Rinfret, A. P., Hane, S.: Depletion of adrenal ascorbic acid following stress in the infant rat. Endocrinology57, 497–499 (1955).

    Google Scholar 

  • Roe, J. H.: Chemical determination of ascorbic, dehydroascorbic and diketogluconic acids. Meth. biochem. Anal.1, 115–139 (1956).

    Google Scholar 

  • Sayers, G., Sayers, M. A.: Regulation of pituitary adrenocorticotropic activity. Fed. Proc.5, 200 (1946).

    Google Scholar 

  • Sayers, G., Sayers, M. A.: Regulation of pituitary adrenocorticotrophic activity during the response of the rat to acute stress. Endocrinology40, 265–273 (1947).

    Google Scholar 

  • Sayers, G., Sayers, M. A.: The pituitary-adrenal system. Ann. N. Y. Acad. Sci.50, 522–539 (1949).

    Google Scholar 

  • Sayers, G., Sayers, M. A., Lewis, H. L., Long, C. N. H.: Effect of adrenocorticotropic hormone on ascorbic acid and cholesterol content of the adrenal. Proc. Soc. exp. Biol. (N. Y.)55, 238–239 (1944).

    Google Scholar 

  • Selye, H.: The physiology and pathology of exposure to stress. Montreal: Acta 1950.

    Google Scholar 

  • Slusher, M. A.: Dissociation of adrenal ascorbic acid and corticosterone response to stress in rats with hypothalamic lesions. Endocrinology63, 412–419 (1958).

    Google Scholar 

  • Stewart, C. R., Salmon, R. J., May, C. D.: Function of the adrenal cortex in ascorbic acid deficiency and scurvy in the monkey. J. Lab. clin. Med.40, 657–663 (1952).

    Google Scholar 

  • Usher, D. R., Kasper, P., Birmingham, M. K.: Comparison of pituitary-adrenal function in rats lesioned in different areas of the limbic system and hypothalamus. Neuroendocrinology2, 157–174 (1967).

    Google Scholar 

  • Vecsei, P., Csalay, L.: Vergleichende Untersuchungen über die Corticosteroidbildung und das morphologische Verhalten der Nebennieren bei chronischen Reizen ausgesetzten Tieren. Z. Vitamin-, Hormon- u. Fermentforsch.14, 57–65 (1965).

    Google Scholar 

  • Winkler, G. K.: Phasisches Verhalten der Nebennierenfunktion sowie verschiedener Stoffwechselparameter nach einmaliger ACTH- oder Corticosteroidgabe beim Menschen. Ulm: Habilitationsschrift der klin. med. Fakultät 1970.

    Google Scholar 

  • Woods, J. W.: Differences in adrenal response to averse conditions in wild and domesticated rats. Fed. Proc.12, 159 (1953).

    Google Scholar 

  • Zarrow, M. X., Philpott, J. W., Denenberg, V. H.: Postnatal changes in the pituitary adrenal axis of the rat. Proc. Soc. exp. Biol. (N. Y.)128, 269–272 (1968).

    Google Scholar 

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Herrn Prof. Dr. H. Autrum danke ich sehr für sein Interesse und die Förderung dieser Arbeit. Besonderer Dank gilt Frau M. Jaenicke für ihre Hilfe bei den chemischen Untersuchungen.

Die Arbeit wurde durch Mittel der Deutschen Forschungsgemeinschaft gefördert.

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von Holst, D. Die Funktion der Nebennieren männlicherTupaia belangeri . J. Comp. Physiol. 78, 289–306 (1972). https://doi.org/10.1007/BF00697659

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