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Anomalies mitochondriales à répartition particulière observées au cours d'une dystrophie musculaire à début pelvien

Mitochondrial anomalies with peculiar distribution in a muscular dystrophy with pelvic onset

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Summary

Mitochondrial abnormalities are reported in some type I fibers, characterized by their oxydative hyperactivity and increased amount of blood vessels. These changes, generally described in “ocular myopathy” are here observed in an adult pelvic dystrophy associated with bilateral ptosis and pharyngeal impairment, without external ophthalmoplegia. A pathogenic approach, in connection with mitochondrial inclusions, is proposed.

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Authors and Affiliations

  1. Laboratoire de Neuropathologie de l'Hôpital Neurologique, B. P. Lyon-Mo-ntchat, F-69394, Lyon Cedex 3, France

    H. Carrier, A. Garde, M. Tommasi, N. Kopp & J. F. Savet

  2. Laboratoire de microscopie électronique de l'unité no 4 de l'I.N.S.E.R.M., Lyon, France

    H. Carrier, A. Garde, M. Tommasi, N. Kopp & J. F. Savet

  3. Service de neurologie de l'Hôpital de l'Antiquaille, Lyon, France

    H. Carrier, A. Garde, M. Tommasi, N. Kopp & J. F. Savet

  4. Centre de microscopie électronique appliquée à la biologie, de la Faculté des Sciences, Lyon, France

    H. Carrier, A. Garde, M. Tommasi, N. Kopp & J. F. Savet

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  1. H. Carrier
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  2. A. Garde
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Carrier, H., Garde, A., Tommasi, M. et al. Anomalies mitochondriales à répartition particulière observées au cours d'une dystrophie musculaire à début pelvien. Acta Neuropathol 30, 295–303 (1974). https://doi.org/10.1007/BF00697012

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  • DOI: https://doi.org/10.1007/BF00697012

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