Summary
Observations concerning transplantation of 5 cases of malignant dysplastic gliomas to the anterior chamber of the guinea-pig eye have been presented. This type of gliomas, composed mainly of cytoplasm-abundant cells, show weak transplantability, slow rate of growth, and particular tendency to degeneration and necrosis. At the same time, in subsequent passages, an intensive proliferation of small-cell component occurs, comparing with cytoplasm-abundant cells.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Gluszcz, A., Alwasiak, J., Rydzewski, Wł., Papierz, W.: Preliminary observations on the transplantability of gliomas. Pat. Pol., Suppl.1, 599–601 (1969) (Polish)
Gluszcz, A.: Dysplastic features in glial tumours. VIth Congres of Neuropathology, Proceedings, pp. 512–529. Paris: Masson et Cie 1970
Gluscz, A.: Grouping of supratentorial gliomas according to their dominant biomorphological features. Acta neuropath. (Berl.)22, 110–126 (1972)
Gluszcz, A., Alwasiak, J., Papierz, W., Lach, B.: Morphological observations of gliomas in the course of repeated transplantations on guinea pigs. Neuropat. Pol.11, 11–21 (1973) (Polish)
Greene, H. S.: Heterologous transplantation of mammalian tumors. J. exp. Med.73, 461–486 (1941)
Greene, H. S., Arnold, H.: The homologous and heterologous transplantation of brain and brain tumours. J. Neurosurg.2, 315–331 (1945)
Herman, M. M., Adams, W. R., Manuelidis, E. E.: The ultrastructure of a human glioblastoma multiforme—derived tumor heterologously transplanted to guinea pig eye and brain. Acta neuropath. (Berl.)8, 321–330 (1967)
Kniseley, R. M., Kernohan, J. W.: Heterologous transplantation of tumors of the human nervous system: implantation in the eye of the guinea pig. J. Neuropath. exp. Neurol.10, 416–419 (1951).
Krementz, E. T., Greene, H. S.: Heterologous transplantation of human neural tumors. Cancer6, 100–110 (1953)
Manuelidis, E. E.: The fate of serial heterologously transplanted glioblastoma multiforme in the eye of the guinea pig. Amer. J. Path.48, 65–89 (1966)
Manuelidis, E. E.: Experiments with tissue culture and heterologous transplantation of tumors. Ann. N. Y. Acad. Sci.159, 409–431 (1969)
Miyawaki, H., Ishi, S.: The heterologous intracerebral transplantation of human brain tumors. Arch. Path.70, 126–137 (1960)
Author information
Authors and Affiliations
Additional information
This investigation was supported by NIH PL 480 Research Agreement No. 05-013-1.
Deceased in 1972.
Rights and permissions
About this article
Cite this article
Gluszcz, A., Alwasiak, J., Papierz, W. et al. Morphological observations of dysplastic gliomas heterotransplanted to experimental animals. Acta Neuropathol 31, 21–28 (1975). https://doi.org/10.1007/BF00696883
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00696883