Summary
A typical case of acquired immune deficiency syndrome (AIDS) has been clinically and morphologically studied. This homosexual man whose past history was significant for i.v. drug abuse and sexually transmitted infection presented several opportunistic infections with a profound impairment of cellmediated immunity. Autopsy showed an intense lymphoid depletion, CMV-generalized infection, and a primary large cell immunoblastic lymphoma of the brain. The present case is discussed in the light of recent literature.
This is a preview of subscription content, log in via an institution to check access.
References
Barre-Sinoussi F, Chermann JC, Rey F, Nugeyre MT, Chamaret S, Gruest J, Dauguet C, Axler-Blin C, Vezinet-Brun F, Rouzioux C, Rozenbaum W, Montagnier L (1983) Isolaion of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 220:868–871
Essex M, McLane MF, Lee TH, Falk L, Howe CWS, Mullins JI (1983) Antibodies to cell membrane antigens associated with human T-cell leukemia virus in patients with AIDS. Science 220:859–862
Fernandez JR, Mouradian J, Moore A, Asch A (1983) Malignant lymphoma with central nervous system involvement in six homosexual men with acquired immunodeficiency syndrome. Lab Invest 48:25 [Abstr]
Gallo RC, Sarin PS, Gelmann EP, Robert-Guroff M, Richardson E, Kalyanaraman VS, Mann D, Sidhu GD, Stahl RE, Zolla-Pazner S, Leibowitch J, Popovic M (1983) Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS). Science 220:865–867
Gelmann EP, Popovic M, Blayney D, Masur H, Sidhu G, Stahl RE, Gallo RC (1983) Proviral DNA of a retrovirus human T-cell leukemia virus in two patients with AIDS. Science 220:862–865
Reichert CM, O'Leary TJ, Levens DL, Simrell CR, Macher AM (1983) Autopsy pathology in the acquired immune deficiency syndrome. Am J Pathol 112:357–382
Schneck SA, Penn L (1971) De novo brain tumours in renaltransplant recipients. Lancet I:983–986
Snider WD, Simpson DM, Nielsen S, Gold JWM, Metroka CE, Posner JB (1983) Neurological complications of acquired immune deficiency syndrome: analysis of 50 patients. Ann Neurol 14:403–418
Author information
Authors and Affiliations
Additional information
Supported by a grant from FEGEFLUC (Fédération Nationale des Groupements des Entreprises Françaises dans la Lutte contre le Cancer — Marseille)
Rights and permissions
About this article
Cite this article
Payan, M.J., Gambarelli, D., Routy, J.P. et al. Primary lymphoma of the brain associated with AIDS. Acta Neuropathol 64, 78–80 (1984). https://doi.org/10.1007/BF00695611
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00695611