Summary
In lung biopsy specimens of 19 patients with congenital heart disease and pulmonary hypertension, in addition to the common features of plexogenic arteriopathy, longitudinal smooth muscle cells were found in small pulmonary arteries. These cells were arranged in bundles or layers, particularly in the intima but sometimes within the media or adventitia of the arteries. They often caused severe narrowing of the lumen. Corrective surgery of the cardiac defect was performed in 14 patients. The results suggested that even when these changes are wide-spread and severe, they do not stand in the way of a favourable postoperative course. In one patient who underwent a banding procedure of the pulmonary artery, virtually complete regression of the smooth muscle layers could be demonstrated in a second biopsy, taken 5 years later during a corrective operation.
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References
Balk AG, Dingemans KP, Wagenvoort CA (1979) The ultrastructure of the various forms of pulmonary arterial intimal fibrosis. Virchows Arch (Pathol Anat] 382:139–150
Bergh Weerman Van den, MA Dingemans KP (1984) Rapid deparaffination for electron microscopy. J Ultrastruct Pathol, in press
Burton AC (1954) Relation of structure to function of the tissue of the wall of blood vessels. Physiol Rev 34:619–642
Hasleton PS, Heath D, Brewer DB (1968) Hypertensive pulmonary vascular disease in states of chronic hypoxia. J Pathol Bact 95:431–440
Heath D (1963) Longitudinal muscle in pulmonary arteries. J Pathol Bact 85:407–412
Heath D (1970) Hypoxic hypertensive pulmonary vascular disease. Prog Resp Res 5:13–17
Hicken P, Heath D, Brewer DB, Whitaker W (1965) The small pulmonary arteries in emphysema. J Pathol Bact 90:107–114
Wagenaar SS, Wagenvoort CA (1978) Experimental production of longitudinal smooth muscle cells in the intima of muscular arteries. Lab Invest 39:370–374
Wagenvoort CA, Wagenvoort N (1973) Hypoxic pulmonary vascular lesions in man at high altitude and in patients with chronic respiratory disease. Pathol Microbiol 39:276–282
Wagenvoort CA, Wagenvoort N (1976) Pulmonary venous changes in chronic hypoxia. Virchows Arch [Pathol Anat] 372:51–56
Wagenvoort CA, Heath D, Edwards JE (1964) The pathology of the pulmonary vasculature. ChC Thomas Publ, Springfield, Ill
Wagenvoort CA, Wagenvoort N, Draulans-Noë Y (1984) Reversibility of plexogenic arteriopathy following banding of the pulmonary artery. J Thorac Cardiovasc Surg 87:876–886
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Wagenvoort, C.A., Keutel, J., Mooi, W.J. et al. Longitudinal smooth muscle in pulmonary arteries. Vichows Archiv A Pathol Anat 404, 265–274 (1984). https://doi.org/10.1007/BF00694892
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DOI: https://doi.org/10.1007/BF00694892