Summary
The chronotropic and inotropic effects of four atrial peptides (cardiodilatin 1–16, atrial natriuretic factor 8–33 and atriopeptin I and III) on the isolated systemic heart ofOctopus vulgaris were studied.
Using a preparation that produces a physiological stroke volume at physiological input pressures, it was found that ANF, atriopeptin I and atriopeptin III exerted both negative chronotropic and inotropic effects. In contrast, cardiodilatin produced a positive inotropic effect.
A dose-response curve of ANF is reported, showing a threshold concentration of about 10−12 M.
The pharmacological and physiological implications of these results are discussed in relation to some characteristics of the cephalopod systemic heart.
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Agnisola, C., Cariello, L., De Santis, A. et al. Chronotropic and inotropic effects of atrial peptides on the isolated systemic heart ofOctopus vulgaris . J Comp Physiol B 158, 637–641 (1989). https://doi.org/10.1007/BF00693001
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DOI: https://doi.org/10.1007/BF00693001