Chronotropic and inotropic effects of atrial peptides on the isolated systemic heart ofOctopus vulgaris
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The chronotropic and inotropic effects of four atrial peptides (cardiodilatin 1–16, atrial natriuretic factor 8–33 and atriopeptin I and III) on the isolated systemic heart ofOctopus vulgaris were studied.
Using a preparation that produces a physiological stroke volume at physiological input pressures, it was found that ANF, atriopeptin I and atriopeptin III exerted both negative chronotropic and inotropic effects. In contrast, cardiodilatin produced a positive inotropic effect.
A dose-response curve of ANF is reported, showing a threshold concentration of about 10−12M.
The pharmacological and physiological implications of these results are discussed in relation to some characteristics of the cephalopod systemic heart.
KeywordsPeptide Human Physiology Stroke Volume Threshold Concentration Atrial Natriuretic Factor
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