Summary
Estimation of activity of five hydrolytic enzymes was made in four histologically different types of human meningiomas derived from surgery. The hydrolytic enzymes examined in 13 tumors included four lysosomal enzymes: β-glucuronidase, N-acetyl-β-d-glucosaminidase (hexosaminidase), β-galactosidase, and acid phosphatase. The fifth enzyme studied was alkaline phosphatase. The one papillary-type meningioma examined appeared to contain generally greater activities of the lysosomal enzymes than the other tumor types. Alkaline phosphatase was decidedly greater in transitional type meningiomas. The correlation of histological types with alkaline phosphatase activity is discussed with regard to previous observations.
References
Büttger, H. W., Scarlato, G., Müller, W., Kemali, D.: Über das Vorkommen und die Verteilung der alkalischen und sauren Phosphatase in Meningeomen. Dtsch. Z. Nervenheilk.176, 67–76 (1957)
Feigin, I., Wolf, A.: The alkaline phosphomonoesterase activities of brain tumors. Arch. Path.67, 670–678 (1959)
Fischer, W., Müller, E.: Untersuchungen über die alkalische Phosphatase in Meningiomen. Enzymol. Biol. Clin.11, 450–458 (1969)
Gluszcz, A.: A histochemical study of some hydrolytic enzymes in tumours of the nervous system. Acta Neuropathol. (Berl.)3, 184–201 (1963)
Inglis, N. R., Kirley, S., Stolbach, L. L., Fishman, W. H.: Phenotypes of the Regan isoenzyme and identity between the placental D-variant and the Nagao isoenzyme. Cancer Res.33, 1657–1661 (1973)
Kaufmann, J. C. E.: Meningiomata and enzymes. J. Lab. Clin. Med.9, 112–118 (1963)
Landow, H., Kabat, E. A., Newmann, W.: Distribution of alkaline phosphatase in normal and in neoplastic tissues of the nervous system. Arch. Neurol. Psychiat. (Chic.)48, 518–530 (1942)
Lowry, O. H., Rosebrough, M. J., Farr, A. L., Randall, R. L.: Protein measurement with the Folin phenol reagent. J. Biol. Chem.193, 265–275 (1951)
Ludwin, S. K., Rubinstein, L. J., Russell, D. S.: Papillary meningioma: A malignant variant of meningioma. Cancer36, 1363–1373 (1975)
Nasu, H.: Fermenthistochemische Untersuchungen an Meningiomen. Acta Neuropathol. (Berl.)3, 627–637 (1964)
Osske, G., Jänisch, W.: Zur Enzymhistochemie der Meningiome. Acta Neuropathol. (Berl.)9, 290–297 (1967)
Russell, D. S., Rubinstein, L. J.: Tumors of meninges and of related tissues. In: Pathology of tumors of the nervous system, 3rd ed., pp. 48–73. Baltimore: Williams and Wilkins 1971
Timperley, W. R., Warnes, T. W.: Alkaline phosphatase in meningiomas. Cancer26, 100–103 (1970)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ramsey, R.B., Fredericks, M., Crafts, D.C. et al. Hydrolytic enzymes in meningiomal subtypes. Acta Neuropathol 49, 63–65 (1980). https://doi.org/10.1007/BF00692221
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00692221