Summary
Gastrocnemius muscle biopsies from 28 patients with chronic renal failure were analyzed with a light microscope after staining with Gomori trichrome stain and after histochemical reactions for ATPase and NADH diaphorase. Nineteen (68%) of the biopsies were pathological. Uremic myopathy was seen in eleven (39%) of the biopsies, eight of which were obtained from subjects on regular hemodialysis. Pure myopathic muscle damage was observed in three (11%), both myopathic and neuropathic muscle damage in eight (29%) and pure neuropathic muscle damage in eight (29%) of the biopsies. Fiber type atrophy and hypertrophy of both types were seen. The most common quantitative findings were Type II atrophy, small mean size and type grouping of Type II fibers, and Type I hypertrophy.
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Adams, R. D.: Pathological reaction of skeletal muscle fibre. In: Disorders of voluntary muscle, Walton, J. N. (ed.), pp. 207–221. Edinburgh, London: Churchill Livingstone 1974
Afifi, A. K., Bergman, R. A., Harvey, J. C.: Steroid myopathy. Clinical, histologic, and cytologic observations. Johns Hopkins Med. J.123, 158–174 (1968)
Afifi, A. K., Bergman, R. A.: Steroid myopathy. A study of the evolution of the muscle lesion in rabbits. Johns Hopkins Med. J.129, 66–86 (1969)
Bundschu, H. D., Suchenwirth, R., Dürr, F.: Enzymhistologische Befunde an der Skelettmuskulatur des Menschen. II. Muskelschwund bei Niereninsuffzienz. Klin. Wochenschr.48, 1389–1397 (1970)
Bundschu, H. D., Schlote, W.: Elektronenmikroskopische Untersuchungen der Skelettmuskulatur bei terminaler Niereninsuffizienz. J. Neurol. Sci.23, 243–254 (1974)
Chazan, J. A., Ambler, M., Kalderon, A., Cohen, J. J., Zacks, J.: Vascular deposits causing ischemic myopathy in uremia. Ann. Intern. Med.73, 73–79 (1970)
Coomes, E. N.: Corticosteroid myopathy. Ann. Rheum. Dis.24, 465–472 (1965)
Dubowitz, V., Pearse, A. G.: Enzymatic activity of normal and diseased muscle. A histochemical study. J. Pathol. Bact.81, 365–378 (1961)
Dubowitz, U., Brooke, M. H.: Definition of pathological changes. Muscle biopsy: A modern approach. London: Sauders 1973
Engel, W. K., Cunningham, G.: Rapid examination of muscle tissue. Neurology (Minneap.)13, 919–923 (1963)
Faludi, G., Gotlieb, J., Meyers, J.: Factors influencing the development of steroid induced myopathies. Ann. NY Acad. Sci.138, 61–67 (1966)
Floyd, M., Ayyar, O. R., Hugson, P., Kerr, D. N. S.: Myopathy in chronic renal failure. Proc. Eur. Dial. Transplant Assoc.6, 203–214 (1969)
Gollnick, P. D., Amstrong, R. B., Saubert IV, C. W., Piehl, K., Salbin, B.: Enzyme activity and fiber composition in skeletal muscle of untrained and trained men. J. Appl. Physiol.33, 312–319 (1972)
Gollnick, P. D., Amstrong, R. B., Saltin, B., Saubert IV, C. W., Sembrowich, W. L., Sheoheka, R. E.: Effect of training on enzyme activity and fiber composition of human skeletal muscle. J. Appl. Physiol.34, 107–111 (1973)
Guth, L., Samaha, F. J.: Procedure for the histochemical demonstration of actomyosin ATPase. Exp. Neurol.28, 365–367 (1970)
Jennekens, F. G. I., Tomlinson, B. E., Walton, J. N.: Data on the distribution of fibre types in five human limb muscles. An autopsy study. J. Neurol. Sci.14, 245–259 (1971)
Mancell, E. L., Patell, A. N., Hirschborn, A. N.: Hypertrophic brachial myopathy. Neurology (Minneap.)24, 1166–1170 (1974)
Mastaglia, F. L., Walton, J. N.: Histological and histochemical changes in skeletal muscle from cases of chronic juvenile and early adult spinal muscular atrophy (the Kubelberg-Welander syndrome). J. Neurol. Sci.12, 15–44 (1971)
Moore, M. J., Rebeiz, J. J., Holden, M., Adams, R. D.: Biometric analyses of normal skeletal muscle. Acta Neuropathol. (Berl.)22, 51–69 (1972)
Parfitt, A. M.: Soft tissue calcification in uremia. Arch. Intern. Med.124, 544–556 (1969)
Pearse, A. G.: Histochemistry, III ed., Oxidoreductases. Edinburgh, London: Churchill Livingstone 1972
Perkoff, G. T., Silber, R., Typer, F. H., Cartwright, G. E., Wintrobe, M. M.: Myopathy due to the administration of therapeutic amounts of 17 hydroxycorticosteroids. Am. J. Med.26, 891–898 (1959)
Rebeiz, J. J., Cauldfield, J. B., Adams, R. D.: Oculopharyngeal dystrophy. A present myopathy. A clinico-pathological study. Excerpta Medica I. C. S.176, 12 (1969)
Rebeiz, J. J., Moore, M. J., Holden, E. M., Adams, R. D.: Variatious in muscle status with age and systemic diseases. Acta Neuropathol. (Berl.)22, 127–144 (1972)
Richards, D. C. B.: Chronic renal disease with secondary hyperparathyreoidism. Br. Med. J. 19511, 167
Richardson, J. A., Herron, G., Reitz, R., Layzer, R.: Ischemic ulcerations of skin and necrosis of muscle in azotemic hyperparathyroidism. Ann. Intern. Med.71, 129–138 (1969)
Tomlinson, B. E., Walton, J. N., Rebeiz, J. J.: The effects of ageing and cachexia upon skeletal muscle. A histopathological study. J. Neurol. Sci.19, 321–346 (1969)
Tyler, H. R.: Neurological aspects of uremia: an overview. Kidney Int. [Suppl. 2], 188–193 (1975)
Walton, J.: Disorders of voluntary muscle. Edinburgh, London: Churchill Livingstone 1974
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Ahonen, R.E. Light microscopic study of striated muscle in uremia. Acta Neuropathol 49, 51–55 (1980). https://doi.org/10.1007/BF00692219
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DOI: https://doi.org/10.1007/BF00692219