Summary
A 73 old patient with very high serum lipids suffered from recurrent peripherad polyneuropathy. Examination of sural nerve showed disorganisation of myelin sheaths ann plasma membrane invaginations into the axons which seems to represent both Schwanl cell and axonal membranes.
An extensive basal membrane hyperplasia and perineural connective tissue proliferation were present. The possibility that these changes are related to the patient's hyperlipemia is discussed.
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Babel, J., Bischoff, A., Spoendlin, H.: Ultrastructure of the peripheral nervous system and sence organs. Stuttgart: G. Thieme 1970.
Bechar, M., Kott, E., Bornstein, B.: Polyneuropathy associated with hyperlipemia. Confin. neurol. (Basel)31, 281–288 (1969).
Bischoff, A.: The ultrastructure of tri-ortho-cresyl phosphate poisoning. Acta neuropath. (Berl.)9, 158–174 (1967).
—: Die alkoholische Polyneuropathie. Dtsch. med. Wschr.96, 317–322 (1971).
Christensen, S., Dollerup, E., Eskjaer Jensen, S.: Idiopathic hyperlipemia, latent diabetes mellitus and severe neuropathy. Acta med. scand.161, 57–68 (1958).
Collins, G. H., Webster, H. de F., Victor, M.: The ultrastructure of myelin and axonal alterations in sciatic nerves of thiamine deficient and chronically starved rats. Acta neuropath. (Berl.)3, 511–521 (1964).
Fulton, J. K.: Essential lipemia, acute gout, peripheral neuritis and myocardial disease in a negro. Response to corticotrophin. Arch. intern Med.89, 303–308 (1952).
Hirano, A.: Progress in neuropathology1, 1–61.
Hirano, A.: Personal communication.
Mei Lui, H.: Ultrastructure of remyelination of peripheral nerves in Landry-Guillain-Barré Syndrome. Acta neuropath. (Berl.)16, 262–265 (1970).
Miyakawa, T., Deshimaru, M., Sumiyoshi, S., Teracka, A., Ugo, N., Hattori, E., Tatetsu, S.: Experimental organic poisoning—pathological changes in peripheral nerves. Acta neuropath. (Berl.)15, 45–55 (1970).
Ochoa, J., Mair, W. G. P.: The normal sural nerve in man. I. Ultrastructure and numbers of fibers and cells. Acta neuropath. (Berl.)13, 197–216 (1969).
——: The normal sural nerve in man. II. Changes in the axons and Schwann cells due to ageing. Acta neuropath. (Berl.)13, 217–239 (1969).
Ohta, M.: Ultrastructure of sural nerve in a case of arsenical neuropathy. Acta neuropath. (Berl.)16, 233–242 (1970).
Prineas, J.: The pathogenesis of Dying-Back polyneuropathies. Part. I. An ultrastructural study of experimental tri-orthocresyl phosphate lutoxication in the cat. J. Neuropath. exp. Neurol.28, 571–597 (1969).
—: The pathogenesis of Dying-Back polyneuropathies. Part II. An ultrastructural study of experimental acrylamide intoxication in the cat. J. Neuropath. exp. Neurol.28, 598 to 621 (1969).
Rawlins, F. A., Uzman, B. G.: Effect of AY-9944, a cholesterol biosynthesis inhibitor, on peripheral nerve myelination. Lab. Invest.23, 184–189 (1970).
——: Retardation of peripheral nerve myelination in mice treated with inhibitors of cholesterol biosynthesis. A quantitative electron microscope study. J. Cell Biol.46, 505–517 (1970).
Schutta, H. S., Neville, H. E.: Effects of cholesterol synthesis inhibitors on the nervous system. Lab. Invest.19, 487 (1968).
Schröder, J. M.: Zur Pathogenese der Isoniazid-Neuropathie. Acta neuropath. (Berl.)16, 301–323 (1970).
Thomas, P. K., Walker, J. G.: Xanthomatous neuropathy in primary biliary cirrhosis. Brain88, 1079–1088 (1965).
Tomonaga, M., Sluga, E.: Zur Ultrastruktur der Pi-Granula. Acta neuropath. (Berl.)15, 56–69 (1970).
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Sandbank, U., Bechar, M. & Bornstein, B. Hyperlipemic polyneuropathy. Acta Neuropathol 19, 290–300 (1971). https://doi.org/10.1007/BF00692149
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DOI: https://doi.org/10.1007/BF00692149