Acta Neuropathologica

, Volume 48, Issue 1, pp 73–75 | Cite as

Encephalopathy in infantile hepatic cirrhosis

  • George A. Jervis
Short Original Communications


The cases are described of two sibs who developed hepatic cirrhosis in early infancy, accompanied by profound mental retardation. Post mortem in one sib there were multiple foci of demyelination with abundant cellular infiltration, scattered throughout the brain. These unusual pathological changes are briefly commented.

Key words

Child Encephalopathy Cirrhosis 


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  1. Plum, F., Hindfelt, B.: The neurological complications of liver diseases. In: Vinken, P. J., Bruyn, G. W. (eds.). Handbook of clinical neurology, Vol. 27, pp. 349–377. Amsterdam: North-Holland 1976Google Scholar
  2. Blackwood, W., Buxton, P. H., Cumming, J. N.: Diffuse cerebral degeneration in infancy. Arch. Dis. Child.38, 193–204 (1963)Google Scholar
  3. Welfring, K. W., Lamvick, V.: Familial progressive poliodystrophy with cirrhosis of the liver. Acta. Paediatr. Scand.56, 295–300 (1963)Google Scholar
  4. Huttenlocher, P. R., Solitaire, G. B., Adams, G.: Infantile diffuse cerebral degeneration with hepatic cirrhosis. Arch. Neurol.33, 186–192 (1976)Google Scholar
  5. Victor, M., Adams, R. D., Cole, M.: Acquired (non-Wilsonian) type of chronic hepato-cerebral degeneration. Medicine (Baltimore)44, 345–396 (1965)Google Scholar
  6. Jellinger, K., Riederer, P., Kleinberger, G., Wukelich, S., Kothbauer, P.: Brain monoamines in human hepatic encephalopathy. Acta. Neuropathol. (Berl.)43, 63–68 (1978)Google Scholar

Copyright information

© Springer-Verlag 1979

Authors and Affiliations

  • George A. Jervis
    • 1
  1. 1.New York State Research Institute for Mental Retardation and Letchworth Village Developmental CenterThiellsUSA

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