Summary
Non-specific esterase has been histochemically studied in 45 cerebral tumors of neurosurgical source. Different substrates and couplers as well as several effectors have been used. The E 600-resistant enzyme activity behaves like acid phosphatase and appears to be in relation with the catabolic or regressive occurrences. This association explains its high value in anaplastic tumors. Also the E 600-sensitive enzyme activity increases with malignancy, but it appears rather in relation with the volume of the cytoplasms.
The different oncotypes and cytotypes are discussed in the light of the obtained results.
Zusammenfassung
In 45 neurochirurgisch gewonnenen Hirntumoren wurde die unspezifische Esterase histochemisch untersucht. Verschiedene Substrate und Kuppler wie auch mehrere Effektoren wurden verwendet. Die E 600-resistente Enzymaktivität verhält sich wie saure Phosphatase und erscheint in Beziehung zu den katabolischen oder regressiven Vorgängen zu stehen. Dies erklärt auch ihre hohe Aktivität in anaplastischen Tumoren. Auch die E 600-empfindliche Enzymaktivität erhöht sich mit der Malignität, sie scheint aber eher in Beziehung zum Plasmavolumen zu stehen. Die verschiedenen Geschwulstarten und Zelltypen werden im Lichte der erhaltenen Befunde diskutiert.
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Schiffer, D., Fabiani, A., Monticone, G.F. et al. Non-specific esterase in cerebral tumors. Acta Neuropathol 10, 143–150 (1968). https://doi.org/10.1007/BF00691308
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DOI: https://doi.org/10.1007/BF00691308